Volume 16, Issue 1 (Spring 2024)
2024, 16(1): 29-34 |
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Ethics code: IR.NKUMS.REC.1400.131
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Bibak A, Bibak B, Moein S, Shakeri F. The effects of ethanolic extract of Punica granatum Peel on Pentylenetetrazole-induced seizures in mice. North Khorasan University of Medical Sciences 2024; 16 (1) :29-34
URL: http://journal.nkums.ac.ir/article-1-2922-en.html
URL: http://journal.nkums.ac.ir/article-1-2922-en.html
1- Student of Medicine, Faculty of Medicine, North Khorasan University of Medical Science, Bojnurd, Iran
2- Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran
3- 1Student of Medicine, Faculty of Medicine, North Khorasan University of Medical Science, Bojnurd, Iran
4- Department of Physiology and Pharmacology, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran ,f_1366_sh@yahoo.com
2- Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran
3- 1Student of Medicine, Faculty of Medicine, North Khorasan University of Medical Science, Bojnurd, Iran
4- Department of Physiology and Pharmacology, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran ,
Abstract: (1026 Views)
Introduction: Pomegranate (Punica granatum L) is an ancient and unique fruit used as antioxidant, antidiabetic, anti-obesity, and antihypertensive. Considering oxidative stress and its relationship with convulsions and the antioxidant properties of pomegranate extract, the present study aimed to investigate the effect of ethanolic extract of Punica granatum peel on pentylenetetrazole (PTZ)-induced seizures in mice.
Method: In this experimental study, male rats were randomly divided into four groups (n=8 in each group, PTZ group, and three groups received 100, 200, and 400 mg/kg of the extract). Thirty minutes after peritoneal injection of different doses of the extract, PTZ (100 mg/kg) was injected, and the mice were immediately transferred to a special cage, and the seizure parameters were evaluated for 60 minutes.
Results: The results implicated that treating with ethanolic extract of Punica granatum peel in different doses of 100, 200, and 400 mg/kg body weight could delay the onset of minimal clonic seizures (MCS) caused by PTZ injection. In addition, doses of 200 and 400 mg/kg delay the onset of generalized tonic-clonic seizures (GTCS) caused by PTZ injection (P<0.001 to P<0.05). The anti-seizure effects of the ethanolic extract of Punica granatum were dose-dependent; therefore, the high doses have the most prophylactic effects against MCS and GTCS seizures (P<0.05).
Conclusion: The results of this study showed that treatment with ethanolic extract of Punica granatum peel has an anti-seizure effect on mice, and the highest anti-seizure effect was observed in the highest dosage
Method: In this experimental study, male rats were randomly divided into four groups (n=8 in each group, PTZ group, and three groups received 100, 200, and 400 mg/kg of the extract). Thirty minutes after peritoneal injection of different doses of the extract, PTZ (100 mg/kg) was injected, and the mice were immediately transferred to a special cage, and the seizure parameters were evaluated for 60 minutes.
Results: The results implicated that treating with ethanolic extract of Punica granatum peel in different doses of 100, 200, and 400 mg/kg body weight could delay the onset of minimal clonic seizures (MCS) caused by PTZ injection. In addition, doses of 200 and 400 mg/kg delay the onset of generalized tonic-clonic seizures (GTCS) caused by PTZ injection (P<0.001 to P<0.05). The anti-seizure effects of the ethanolic extract of Punica granatum were dose-dependent; therefore, the high doses have the most prophylactic effects against MCS and GTCS seizures (P<0.05).
Conclusion: The results of this study showed that treatment with ethanolic extract of Punica granatum peel has an anti-seizure effect on mice, and the highest anti-seizure effect was observed in the highest dosage
Type of Study: Orginal Research |
Subject:
Basic Sciences
Received: 2023/12/26 | Accepted: 2024/02/29 | Published: 2024/03/26
Received: 2023/12/26 | Accepted: 2024/02/29 | Published: 2024/03/26
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