Journal of North Khorasan

Abstract

Background  & Objective:  Aspirin  is widely  used as analgesic  and anti-inflammatory    drug. The aim of this study was to investigate  the side effects  of aspirin  on placenta.

Materials  and  Methods:  Forty  balb/c  female  mice  were  randomly   divided  into  experimental   and  placebo groups;  further  each  placebo  and  experimental   groups  were  divided  into  groups   1 &  2. All  animals  were mated  with  male  mice.  Pregnant  experimental   mice were treated  daily  by 200 mg/  kg aspirin  dissolved  in  I ml  saline  (through   gavage)  during  pregnancy   while,  the  animals  of  placebo   groups  received   saline  (1 ml

/kg/day).  Mice  in groups  1(both  placebo  and experimental)   were anesthetized   and  killed  at day  10 and mice

in groups  2 (both  placebo  and experimental)   were killed  at day 20 of gestation.  Placentas  were removed  and processed  for histological  evaluation  using routine  histological  procedures.

Results:  Abortion   occurred   in two  pregnant   mice  in  experimental   group   1 and  in seven  in experimental group 2. There was no abortion  in placebo  groups.  Pathologic  changes  i.e. syncicial  degeneration   and fibrotic tissue  formation  were  present  in placental  tissues  of both  experimental   groups  but  no histological   changes were observed  in placebo  groups.

Conclusion:  Side  effects  of aspirin  such  as gastrointestinal   bleeding   has  been  reported   in several  studies. Placental  bleeding  and subsequently   abortion  was  observed  in this  study.  Therefore,   it can be proposed  that consumption   of aspirin  may  cause  bleeding  and disconnectivity   in placenta  and  may  cause  abortion.  It may be suggested  that aspirin  should  be used in pregnant  women  with caution.