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JNKUMS 2021, 12(4): 94-99 Back to browse issues page
The Effect of Moderate Intensity Continuous Training on Skeletal Muscle Autophagy Biomarkers in Elderly Male Rats
Saghar Delshad, Ali Yaghoubi , Najme Rezaeian
Abstract:   (1489 Views)
Introduction: Aging is associated with muscle atrophy or sarcopenia. Autophagy is a process that reduces muscle atrophy; however, the efficiency of this process decreases with age. Exercise improves sarcopenia and the process of autophagy by activating signaling pathways. Therefore, the aim of the present study was to investigate the effect of moderate-intensity continuous training (MICT) on protein levels of ULK1, beclin1, Sestrins2, and AMPK phosphorylation in skeletal muscle of elderly male rats.
Methods: Twenty elderly male Wistar rats (18 months years old) were randomly divided into two groups of 1) MCIT 2) control (10 ones in each). MICT protocol included eight weeks of running on treadmill at intensity of 65-70 percentage of Vo2max with speed of 18-29 meter per minute for 25-40 minutes per sessions and five sessions per week. Muscle tissue samples were taken from gastrocnemius muscle at 48 hours after the last training session. Independent t-test was used to analyze the data and P value <0.05 considered significant.
Results: Beclin1 protein levels were significantly increased in the MICT group compared to the control group (P = 0.001). However, the protein levels of ULK1, Sestrins2 and p-AMPK in the MICT group did not change significantly compared to the control group (P > 0.05).
Conclusions: It seems that MICT is not a suitable training method to activate autophagic pathways and subsequently improve the effects of aging in the skeletal muscles of elderly rats.
Keywords: Exercise Training Autophagy Sestrins 2 Aging
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Type of Study: Review Article | Subject: Basic Sciences
Received: 2021/05/17 | Accepted: 2021/02/28 | Published: 2021/02/28
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Delshad S, Yaghoubi A, Rezaeian N. The Effect of Moderate Intensity Continuous Training on Skeletal Muscle Autophagy Biomarkers in Elderly Male Rats. JNKUMS. 2021; 12 (4) :94-99
URL: http://journal.nkums.ac.ir/article-1-2255-en.html


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Volume 12, Issue 4 (2-2021) Back to browse issues page
مجله دانشگاه علوم پزشکی خراسان شمالی Journal of North Khorasan University of Medical Sciences
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