Volume 9, Issue 2 (10-2017)
2017, 9(2): 263-270 |
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Soofi Zamiri F, Hajinezhad M, Samzadeh-Kermani A, Jahantigh M, Ahmadpour S. Comparison the effects of ZnO nanoparticles and
ZnO nanocomposites on Lipid Peroxidation in Rats
. North Khorasan University of Medical Sciences 2017; 9 (2) :263-270
URL: http://journal.nkums.ac.ir/article-1-1205-en.html
URL: http://journal.nkums.ac.ir/article-1-1205-en.html
1- , hajinezhad@uoz.ac.ir
Abstract: (3998 Views)
Background & objectives:The purpose of this study was to compare the effect of Zinc oxide nanoparticles and Zinc oxide nanocomposites on serum lipid peroxidation in rats.
Materials and Methods:Fifty-sixadult male wistar rats were divided into 8 groups (7 rats in each group: one control group and six treatment group).Rats in treatment group received intraperitoneal injections of ZnO nanoparticles (10, 20 and 40 mmol/ml) and ZnO nanocomposites (10, 20 and 40 mmol/ml) for 28 days.Control rats received distilled water for 28 days. Serum lipid peroxidatin was assayed and compared with one-way ANOVA and tukey statistical analysis. Statistical significance was set at P < 0.05.
Results:Intraperitoneal injection of ZnO nanoparticles at 20 and 40 mmol/ml significantly decreased serum lipid peroxidatin in comparisonwith the control group (P < 0.05). In contrast, intraperitoneal injection of ZnO nanocomposites had notany significant effect on lipid peroxidatin in comparisonwith the control group.
Conclusion:ZnO nanoparticles aremore effective in reduction of lipid peroxidation in comparison with the ZnO nanocomposites.
Materials and Methods:Fifty-sixadult male wistar rats were divided into 8 groups (7 rats in each group: one control group and six treatment group).Rats in treatment group received intraperitoneal injections of ZnO nanoparticles (10, 20 and 40 mmol/ml) and ZnO nanocomposites (10, 20 and 40 mmol/ml) for 28 days.Control rats received distilled water for 28 days. Serum lipid peroxidatin was assayed and compared with one-way ANOVA and tukey statistical analysis. Statistical significance was set at P < 0.05.
Results:Intraperitoneal injection of ZnO nanoparticles at 20 and 40 mmol/ml significantly decreased serum lipid peroxidatin in comparisonwith the control group (P < 0.05). In contrast, intraperitoneal injection of ZnO nanocomposites had notany significant effect on lipid peroxidatin in comparisonwith the control group.
Conclusion:ZnO nanoparticles aremore effective in reduction of lipid peroxidation in comparison with the ZnO nanocomposites.
Type of Study: Orginal Research |
Subject:
Basic Sciences
Received: 2017/09/24 | Accepted: 2017/09/24 | Published: 2017/09/24
Received: 2017/09/24 | Accepted: 2017/09/24 | Published: 2017/09/24
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