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JNKUMS 2018, 10(1): 105-116 Back to browse issues page
Effect of a Ten-week Endurance Training Program on Tissue and Stereological Structure of Liver Parenchyma, and Serum Levels of Cholestrole and Triglyceride in Ovariectomized Rats
Leila Gharahcholoo * , Elaheh Talebi-Garakani , Rozita Fathi , Gholamreza Hamidian
Abstract:   (540 Views)
Introduction: With better understanding of the various structural and biochemical changes during menopause in the liver, as well as the effect of exercises on such parameters, liver changes and diseases can be managed during this period. Therefore, the current study aimed at investigating the effect of a 10-week endurance training program on changes in tissue and stereological structure of the liver parenchyma, as well as the serum levels of cholesterol and triglyceride in ovariectomized rats.
Methods: A total of 20 rats were randomly divided to four groups as healthy control, healthy training, ovariectomy, and training ovariectomy. Groups received the training program three weeks after the surgery. The training protocol was a 10-week treadmill-running. The rat liver and blood samples were taken 48 hours after the last training session.
Results: Based on the study findings, ovariectomy damaged the tissue structure, increased liver parenchyma volume (P < 0.009), increased the size of liver (P < 0.000), reduced the total number of hepatocytes (P < 0.001) and increased the number of dual-core hepatocyte cells (P < 0.004) compared with those of the control group. The liver parenchymal volume decreased with training (P < 0.270). Also, serum levels of triglyceride and cholesterol were significantly increased with ovariectomy and significantly decreased with training.
Conclusions: It seems that endurance training improves the function and structure of the damaged liver following ovariectomy; therefore, the arrangement and morphology of hepatocytes and parenchymal liver cells in the training ovariectomy group were more normal than those of the ovariectomy group.
Keywords: Exercise Ovariectomy Menopause Liver Histology Stereology
Full-Text [PDF 1666 kb]   (522 Downloads)    
Type of Study: Orginal Research | Subject: Basic Sciences
Received: 2018/06/26 | Accepted: 2018/06/26 | Published: 2018/06/26
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Gharahcholoo L, Talebi-Garakani E, Fathi R, Hamidian G. Effect of a Ten-week Endurance Training Program on Tissue and Stereological Structure of Liver Parenchyma, and Serum Levels of Cholestrole and Triglyceride in Ovariectomized Rats. JNKUMS. 2018; 10 (1) :105-116
URL: http://journal.nkums.ac.ir/article-1-1421-en.html


Volume 10, Issue 1 (4-2018) Back to browse issues page
مجله دانشگاه علوم پزشکی خراسان شمالی Journal of North Khorasan University of Medical Sciences
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