Abstract HIV positive patients have incubation period which is usually after infection and during the primary stage (acute retroviral syndrome). HIV positive patients are often unaware of their infections and early clinical manifestation of this infection is associated with an infection resulted from immuno suppression. Neurologic complications of HIV include spinal cord and cranial nerves diseases. Vacuolar myelopathy is a neurologic complication with 20% prevalence in AIDS stage. Here a 20 years old HIV positive case , without definite HIV risk factors and early clinical manifestation of quadriparesis resulted from vacuolar myelopathy is being reported. The goal of this report is to remind the importance and attention of assymptomatic HIV carriers and variety of contagious transmission and correct management of these complications to health community and authorities .