Journal of North Khorasan

Abstract Background & objectives: Diabetes mellitus is an important medicinal problem in the world. Traditional cure of diabetes with plants and their extracts has been recognized since time. Hypoglycemic effects of Laurus nobilis has been investigated in recent years. The aim of this study was to investigate L. nobilis effects on blood biochemical parameters in alloxan-induced diabetic rats. Material & Methods: In present study, 40 male rats divided into 4 groups: Group 1(normal group) was treated by saline. Group 2(diabetic control) was treated by alloxan monohydrate (120 mg/kg, i.p). Group 3(extract group) diabetic rats that received hydro-alcoholic extract of L.nobilis(100mg /kg, i.p) for 10 days. Group 4(glibenclamide group) diabetic rats that received glibenclamide(500mcg /kg, i.p) for 10 days. Blood was collected and then, levels of serum glucose, lipoproteins (HDL, LDL, and VLDL), triglycerides, and total cholesterol were assessed by enzymatic kits. Results: The results showed significant reduction of glucose, triglyceride, VLDL and LDL levels in group 3 in comparison with group 2(P<0.001). Glucose and LDL reduction by L.nobilis was similar to glibenclamide and reduction of TG and VLDL by L.nobilis were more than glibenclamide. L.nobilis also could increased HDL levels significantly in comparison with group 2(P<0.001) that this effect is similar to glibenclamide effect on HDL . Conclusion: According to this results, L.nobilis extractbe lowerd serum glucose and lipids in diabetic rats, therefore, it may be used in diabetic patients.