Volume 13, Issue 2 (9-2021)
2021, 13(2): 70-76 |
Back to browse issues page
Ethics code: IR.1399,004IR.IAU.M.REC.1399.004
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Arjmand A, Abedi B, Hosseini S A, Ramezani S. The Effect of Resistance Training with Tribulus terrestris Extract on Apoptosis of Heart Tissue in Rats. North Khorasan University of Medical Sciences 2021; 13 (2) :70-76
URL: http://journal.nkums.ac.ir/article-1-2363-en.html
URL: http://journal.nkums.ac.ir/article-1-2363-en.html
1- PhD Student, Department of Physical Education, Mahallat Branch, Islamic Azad University, Mahallat, Iran
2- Associate Professor, Department of Physical Education, Faculty of Humanities, Islamic Azad University, Mahallat Branch, Mahallat, Iran , abedi_bahram2000@yahoo.com
3- Instructor of Physical Education and Sports Science Department, Faculty of Sports Sciences, Arak University, Arak, Iran
4- Associate Professor, Department of Physical Education and Sport Sciences, Islamic Azad University, Marvdasht Branch, Marvdasht, Iran
2- Associate Professor, Department of Physical Education, Faculty of Humanities, Islamic Azad University, Mahallat Branch, Mahallat, Iran , abedi_bahram2000@yahoo.com
3- Instructor of Physical Education and Sports Science Department, Faculty of Sports Sciences, Arak University, Arak, Iran
4- Associate Professor, Department of Physical Education and Sport Sciences, Islamic Azad University, Marvdasht Branch, Marvdasht, Iran
Abstract: (1931 Views)
Introduction: Apoptosis is a regulated process that ensures cell tissue homeostasis. The aim of this study was to investigate the effect of a period of resistance training and consumption of Tribulus terrestris extract on cardiac tissue apoptosis in rats.
Methods: In this experimental study, 24 Sprague-Dovali rats with a weight range of 150 to 200 g and a mean age of 8 weeks were randomly divided into four groups (control, Tribulus terrestris extract, resistance training and resistance training + Tribulus terrestris). Resistance training program was performed for eight weeks and three sessions per week. Tribulus terrestris extract (100 mg / kg body weight) was injected intraperitoneally daily. Expression of caspase-3 BAX and BCL2 of heart tissue was measured by Real time PCR. . Kolmogorov-Smirnov test was used to investigate the normality of the findings and one-way analysis of variance with Tukey post hoc test in SPSS software was used to analyze the findings (P≥0.05).
Results: There was a significant difference between the mean of caspase-3 BAX and BCL2 of cardiac tissue (P ≤ 0.001). (P ≤ 0.001). Also, BAX gene expression was significantly reduced in the resistance training group + thistle compared to the control, tribulus terrestris and resistance training groups (P = 0.002). However, the levels of BCl2 as an anti-apoptotic agent in the resistance training group + tribulus terrestris were significantly increased compared to the control groups, tribulus terrestris and resistance training (P ≤ 0.001).
Conclusions: According to the findings of the present study, it seems that resistance training and tribulus terrestris supplementation can have a preventive effect on cardiac apoptosis by reducing the expression of caspase 3 and BAX gene and increasing BCl2.
Methods: In this experimental study, 24 Sprague-Dovali rats with a weight range of 150 to 200 g and a mean age of 8 weeks were randomly divided into four groups (control, Tribulus terrestris extract, resistance training and resistance training + Tribulus terrestris). Resistance training program was performed for eight weeks and three sessions per week. Tribulus terrestris extract (100 mg / kg body weight) was injected intraperitoneally daily. Expression of caspase-3 BAX and BCL2 of heart tissue was measured by Real time PCR. . Kolmogorov-Smirnov test was used to investigate the normality of the findings and one-way analysis of variance with Tukey post hoc test in SPSS software was used to analyze the findings (P≥0.05).
Results: There was a significant difference between the mean of caspase-3 BAX and BCL2 of cardiac tissue (P ≤ 0.001). (P ≤ 0.001). Also, BAX gene expression was significantly reduced in the resistance training group + thistle compared to the control, tribulus terrestris and resistance training groups (P = 0.002). However, the levels of BCl2 as an anti-apoptotic agent in the resistance training group + tribulus terrestris were significantly increased compared to the control groups, tribulus terrestris and resistance training (P ≤ 0.001).
Conclusions: According to the findings of the present study, it seems that resistance training and tribulus terrestris supplementation can have a preventive effect on cardiac apoptosis by reducing the expression of caspase 3 and BAX gene and increasing BCl2.
Type of Study: Orginal Research |
Subject:
Basic Sciences
Received: 2020/10/4 | Accepted: 2020/12/15 | Published: 2021/09/14
Received: 2020/10/4 | Accepted: 2020/12/15 | Published: 2021/09/14
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
