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JNKUMS 2011, 3(1): 43-48 Back to browse issues page
Effect of ovarian hormone deletion on the analgesic effect of morphine in rats
M Hosseini , Z Taiarani , R Karami , B Bibak
Abstract:   (942 Views)

Abstract Background and Objective: The present study was carried out to evaluate the antinociceptive effect of morphine in ovariectomized female rats in comparison with naïve and estradiole-treated ovariectomized rats. Matial and Methods: 30 female rats were divided into 3 groups: 1) Sham (control group) 2) OVX (ovarictomized) 3) OVX Est. (ovarictomized and estradiole treated). Estradiol valerate (2mg/kg/week, i.m.) was injected in the animals of OVX Est. The animals of Sham and OVX groups received 2ml/kg/week saline instead of estradiole. The hot plate test was carried out as a base record 15 min before injection of morphine (10 mg/kg S.C.) and consequently it was repeated 5 times, every15 minutes after injection. The results were compared using one way and repeated-measure analysis of variance (ANOVA) followed by post-hoc Tukey’s test. Differences were considered statistically significant when P <0.05. Results: The reaction times after injection of morphine in sham and OVX Est groups were significantly higher than basal reaction time (P <0.05 and P <0.001) but in OVX group there were no significant differences. However, the reaction times after injection of morphine in OVX, OVX Est and sham groups were not significantly different. Conclusion: It is concluded that ovarian hormones change analgesic effects of morphine in rats.

Keywords: Keywords: Morphine, Ovariectomy, Pain, Rat
Full-Text [PDF 316 kb]   (304 Downloads)    
Type of Study: Orginal Research | Subject: Basic Sciences
Received: 2015/01/5 | Accepted: 2015/01/5 | Published: 2015/01/5
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Hosseini M, Taiarani Z, Karami R, Bibak B. Effect of ovarian hormone deletion on the analgesic effect of morphine in rats. JNKUMS. 2011; 3 (1) :43-48
URL: http://journal.nkums.ac.ir/article-1-238-en.html

Volume 3, Issue 1 (Spring 2011 2011) Back to browse issues page
مجله دانشگاه علوم پزشکی خراسان شمالی Journal of North Khorasan University of Medical Sciences
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