Volume 13, Issue 3 (12-2021)
2021, 13(3): 43-50 |
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Ethics code: IR.BMSU.BAQ.REC.1398.061
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Taghipour R, Zaree Mahmoudabadi A, Jangravi Z, Javadi H, Rashedi Osqueei M, Mousavi N et al . Evaluation of the Effect of Erynjium Alcoholic Extract on Increasing Insulin Sensitivity: By Evaluating Hyperglycemia and Dyslipidemia in an Animal Model of Insulin Resistance. North Khorasan University of Medical Sciences 2021; 13 (3) :43-50
URL: http://journal.nkums.ac.ir/article-1-2433-en.html
URL: http://journal.nkums.ac.ir/article-1-2433-en.html
Reza Taghipour1 
, Ali Zaree Mahmoudabadi * 
2, Zohreh Jangravi3 , Hamidreza Javadi4 , Mohadeseh Rashedi Osqueei5 , Naser Mousavi1 , Mohammad Raeeszadeh6
, Ali Zaree Mahmoudabadi * 2, Zohreh Jangravi3 , Hamidreza Javadi4 , Mohadeseh Rashedi Osqueei5 , Naser Mousavi1 , Mohammad Raeeszadeh6
1- M.Sc., Biochemical Department of Medical Faculty, Baqiyatallah University of Medical Sciences, Tehran, Iran
2- Professor, Department of Biochemistry and Nanobiotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran-Iran , zareiali4031@yahoo.com
3- Assistant Professor, Department of Biochemistry and Nanobiotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran-Iran
4- Assistant Professor, Nanobiotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran-Iran
5- M.Sc., Department of Biochemistry, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran-Iran
6- Assistant Professor, Surgery Department of Medical Faculty, Baqiyatallah University of Medical Sciences, Tehran, Iran
2- Professor, Department of Biochemistry and Nanobiotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran-Iran , zareiali4031@yahoo.com
3- Assistant Professor, Department of Biochemistry and Nanobiotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran-Iran
4- Assistant Professor, Nanobiotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran-Iran
5- M.Sc., Department of Biochemistry, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran-Iran
6- Assistant Professor, Surgery Department of Medical Faculty, Baqiyatallah University of Medical Sciences, Tehran, Iran
Abstract: (1525 Views)
Introduction: Insulin resistance is a common complication of obesity in communities, so effective and available treatment for this disorder is necessary. The aim of this study was to investigate the effect of Eryngium Billardieri extract on insulin resistance in animal models.
Methods: 30 Wistar rats were prepared from Baqiyatallah University Animal house and randomly divided into control (N = 6) and case (N = 24) groups. After preparing a blood sample,they were fed a normal and high-fat diet for 13 weeks, respectively, and at the end, blood samples were taken again and serum cholesterol, FBS, TG, OGTT and insulin were measured. The case group was then randomly divided into: positive control, E. Billardieri, pioglitazone, and E. Billardieri + pioglitazone groups (N = 6) and treated with (50mg / kg) E. Billardieri and (5mg / kg) pioglitazone by gavage daily for 4 weeks. At the end of treatment, serum samples were prepared again and serum factors were measured by standard laboratory methods.
Results: Treatment with high-fat diet significantly increased the weight of animals (P <0.0001). Cholesterol, sugar, triglyceride and insulin levels also increased significantly but HDL-C decreased (P <0.05). HOMA-IR and TYC indices showed a significant increase (P <0.05). Treatment of animals significantly increased HDL-C and decreased other factors (P <0.01).
Conclusions: The findings of this study indicate a reduction in insulin resistance by E. Billardieri extract, so it can probably be used as a complementary or alternative treatment for insulin resistance
Methods: 30 Wistar rats were prepared from Baqiyatallah University Animal house and randomly divided into control (N = 6) and case (N = 24) groups. After preparing a blood sample,they were fed a normal and high-fat diet for 13 weeks, respectively, and at the end, blood samples were taken again and serum cholesterol, FBS, TG, OGTT and insulin were measured. The case group was then randomly divided into: positive control, E. Billardieri, pioglitazone, and E. Billardieri + pioglitazone groups (N = 6) and treated with (50mg / kg) E. Billardieri and (5mg / kg) pioglitazone by gavage daily for 4 weeks. At the end of treatment, serum samples were prepared again and serum factors were measured by standard laboratory methods.
Results: Treatment with high-fat diet significantly increased the weight of animals (P <0.0001). Cholesterol, sugar, triglyceride and insulin levels also increased significantly but HDL-C decreased (P <0.05). HOMA-IR and TYC indices showed a significant increase (P <0.05). Treatment of animals significantly increased HDL-C and decreased other factors (P <0.01).
Conclusions: The findings of this study indicate a reduction in insulin resistance by E. Billardieri extract, so it can probably be used as a complementary or alternative treatment for insulin resistance
Type of Study: Orginal Research |
Subject:
Basic Sciences
Received: 2021/03/13 | Accepted: 2021/05/11 | Published: 2021/12/1
Received: 2021/03/13 | Accepted: 2021/05/11 | Published: 2021/12/1
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