Volume 14, Issue 2 (9-2022)
2022, 14(2): 66-74 |
Back to browse issues page
Ethics code: EE97/3/24-61254/SCU.AC.IR
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Moghaddasi R, Moazedi A A, Ghotbeddin Z, Akhond M R. Study of the Combined Effect of Low Frequency Stimulation and Carbamazepine on Motor and Balance Behavior Indices during Unilateral Kindling in the CA1 Region of the Dorsal Hippocampus in Adult Male Rats. North Khorasan University of Medical Sciences 2022; 14 (2) :66-74
URL: http://journal.nkums.ac.ir/article-1-2618-en.html
URL: http://journal.nkums.ac.ir/article-1-2618-en.html
1- PhD of Physiology, Department of Biology, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran , ghr.moghaddasi@gmail.com
2- Professor of Physiology, Department of Biology, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran
3- Associate Professor of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
4- Assistant Professor, Department of Statistics, Mathematical Sciences and Computer Faculty, Shahid Chamran University of Ahvaz, Ahvaz, Iran
2- Professor of Physiology, Department of Biology, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran
3- Associate Professor of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
4- Assistant Professor, Department of Statistics, Mathematical Sciences and Computer Faculty, Shahid Chamran University of Ahvaz, Ahvaz, Iran
Abstract: (879 Views)
Introduction: In this study, the combined effects of low frequency stimulation (LFS) and carbamazepine (CBZ) were investigated on the motor behavior and balance indices of adult male rats during dorsal hippocampal epilepsy by electrical kindling method.
Method: In this experimental study, 56 adult male Wistar rats were randomly divided into 8 groups. Kindling stimulations were performed rapidly in the dorsal hippocampus. In other groups, carbamazepine was injected before kindling. LFS stimulation was also performed immediately after kindling in the target groups. The animals' motor behavior and balance indices were measured using open field and rotating bar tests. Behavioral data analysis was performed using analysis of variance and Kruskal-Wallis tests.
Results: The results showed that the ability to maintain balance in the rotating rod test in the CBZ20+K+LFS and CBZ40+K+LFS groups had a significant increase compared to the Kindle and K+LFS groups. Analysis of the motor behavior of Kindley mice showed that the search behavior of the drug and LFS groups has significantly increased compared to the K+LFS and K groups. Also, in the study of bipedal standing index, the combined groups showed a significant decrease compared to K+LFS and drug-receiving groups.
Conclusion: The duration of balance on the rotating bar in the drug and LFS groups showed a significant increase compared to the Kindle and K+LFS groups (P <0.05). Comparison of the mean number of bipedal standing indices indicated significant decrease in the drug and LFS groups compared to the Kindle and K+LFS groups (P <0.05).
Method: In this experimental study, 56 adult male Wistar rats were randomly divided into 8 groups. Kindling stimulations were performed rapidly in the dorsal hippocampus. In other groups, carbamazepine was injected before kindling. LFS stimulation was also performed immediately after kindling in the target groups. The animals' motor behavior and balance indices were measured using open field and rotating bar tests. Behavioral data analysis was performed using analysis of variance and Kruskal-Wallis tests.
Results: The results showed that the ability to maintain balance in the rotating rod test in the CBZ20+K+LFS and CBZ40+K+LFS groups had a significant increase compared to the Kindle and K+LFS groups. Analysis of the motor behavior of Kindley mice showed that the search behavior of the drug and LFS groups has significantly increased compared to the K+LFS and K groups. Also, in the study of bipedal standing index, the combined groups showed a significant decrease compared to K+LFS and drug-receiving groups.
Conclusion: The duration of balance on the rotating bar in the drug and LFS groups showed a significant increase compared to the Kindle and K+LFS groups (P <0.05). Comparison of the mean number of bipedal standing indices indicated significant decrease in the drug and LFS groups compared to the Kindle and K+LFS groups (P <0.05).
Type of Study: Orginal Research |
Subject:
Basic Sciences
Received: 2022/01/5 | Accepted: 2022/05/24 | Published: 2022/09/11
Received: 2022/01/5 | Accepted: 2022/05/24 | Published: 2022/09/11
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
