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:: Volume 6, Issue 1 (Spring 2014 2014) ::
JNKUMS 2014, 6(1): 133-138 Back to browse issues page
Study of methanol extract of Cyprus Longus on visceral pain by writhing test in mice
M Ghasemi , E Golmakani , T Ahmadzadeh sani , H Kamali , A Akaberi , B Bibak
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Abstract Background & Objectives: Cyprus Longus is a traditional herbal medicine widely used as a mild sedative, spasmolytic and antibacterial agent. In this study the effect of methanol extract of Cyprus Longus on visceral pain was investigated. Materials & Methods: This experimental study performed on 40 N-MRI male mice (28±3g). Animals were randomly grouped into control, positive control and receivers of Cyprus Longus extract. Control and positive control groups received normal saline and indomethacin (5mg/kg), respectively. Treatment groups were injected with 100 and 200 mg/kg of methanol extract of Cyprus Longus. All injections were performed intraperitonealy (IP). Animals were injected with acetic acid 0.6% (10ml/kg) for visceral pain induction, 30 minutes after of each intraperitoneal administration. Antinociceptive effects were recorded by counting the number of writhes during 30 minutes. The data were analyzed by SPSS statistical software and One-Way ANOVA test. The significant was shown with (p <0.05). Results: methanol extract of Cyprus Longus at 100 and 200 mg/kg and Indomethacin (5mg/kg) induced a significant reduction in pain response when compared with control group. Conclusion: This study confirms the antinociceptive properties of Cyprus Longus in comparison with Indomethacin, however other studies are necessary to confirm analgesic effect of Cyprus Longus.

Keywords: Keywords: Cyprus Longus, Visceral Pain, Indomethacin, Writhing Test
Full-Text [PDF 529 kb]   (520 Downloads)    
Type of Study: Orginal Research | Subject: Basic Sciences
Received: 2015/03/16 | Accepted: 2015/03/16 | Published: 2015/03/16
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Ghasemi M, Golmakani E, Ahmadzadeh sani T, Kamali H, Akaberi A, Bibak B. Study of methanol extract of Cyprus Longus on visceral pain by writhing test in mice. JNKUMS. 2014; 6 (1) :133-138
URL: http://journal.nkums.ac.ir/article-1-326-en.html


Volume 6, Issue 1 (Spring 2014 2014) Back to browse issues page
مجله دانشگاه علوم پزشکی خراسان شمالی Journal of North Khorasan University of Medical Sciences
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