Volume 17, Issue 4 (Winter 2026)
2026, 17(4): 77-86 |
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Ethics code: IR.IAU.URMIA.REC.1403.183
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Jahanghir A, Hosseinchi M, Mohammadi T. Protective Effects of Alhagi maurorum Extract on Epididymal Sperm Parameters and In Vitro Fertilization in Rats with Experimental Varicocele. North Khorasan University of Medical Sciences 2026; 17 (4) :77-86
URL: http://journal.nkums.ac.ir/article-1-3320-en.html
URL: http://journal.nkums.ac.ir/article-1-3320-en.html
1- Doctor of Veterinary Medicine, Faculty of Veterinary Medicine, Ur.C., Islamic Azad University, Urmia, Iran
2- Department of Basic Sciences, Faculty of Veterinary Medicine, Ur.C., Islamic Azad University, Urmia, Iran ,hosseinchi.m@iau.ac.ir
3- Department of Basic Sciences, Faculty of Veterinary Medicine, Ur.C., Islamic Azad University, Urmia, Iran
2- Department of Basic Sciences, Faculty of Veterinary Medicine, Ur.C., Islamic Azad University, Urmia, Iran ,
3- Department of Basic Sciences, Faculty of Veterinary Medicine, Ur.C., Islamic Azad University, Urmia, Iran
Abstract: (34 Views)
Introduction: Varicocele is characterized by abnormal dilation and twisting of the pampiniform plexus veins in the spermatic cord. It is the leading surgically treatable cause of male infertility. This study examined the protective effects of Alhagi maurorum (AM) extract on sperm parameters and in vitro fertilization (IVF) outcomes in a rat model of varicocele.
Method: In this experimental study, 60 male rats were randomly assigned into five groups (n=12): control, varicocele, varicocele with high-dose AM (200 mg/kg), varicocele with medium-dose AM (100 mg/kg), and varicocele with low-dose AM (50 mg/kg). After 60 days of treatment, malondialdehyde levels, total antioxidant capacity (TAC), sperm parameters, and IVF outcomes were evaluated.
Results: The results showed that the varicocele group significantly decreased (P<0.05) in TAC, sperm count, motility, viability, as well as in the number of zygotes, two-cell embryos, and blastocysts, compared to the control group. AM administration significantly (P<0.05) improved sperm parameters, fertilization rates, and embryo development.
Conclusion: These results indicate that AM can reduce the harmful effects of varicocele on fertility in rats, likely due to its antioxidant properties and ability to neutralize free radicals.
Method: In this experimental study, 60 male rats were randomly assigned into five groups (n=12): control, varicocele, varicocele with high-dose AM (200 mg/kg), varicocele with medium-dose AM (100 mg/kg), and varicocele with low-dose AM (50 mg/kg). After 60 days of treatment, malondialdehyde levels, total antioxidant capacity (TAC), sperm parameters, and IVF outcomes were evaluated.
Results: The results showed that the varicocele group significantly decreased (P<0.05) in TAC, sperm count, motility, viability, as well as in the number of zygotes, two-cell embryos, and blastocysts, compared to the control group. AM administration significantly (P<0.05) improved sperm parameters, fertilization rates, and embryo development.
Conclusion: These results indicate that AM can reduce the harmful effects of varicocele on fertility in rats, likely due to its antioxidant properties and ability to neutralize free radicals.
Type of Study: Orginal Research |
Subject:
Basic Sciences
Received: 2025/06/10 | Accepted: 2025/09/14 | Published: 2026/01/1
Received: 2025/06/10 | Accepted: 2025/09/14 | Published: 2026/01/1
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