Volume 18, Issue 1 (Spring 2026)
2026, 18(1): 43-48 |
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Ghofrani F, Bibak B, Ramezanzadeh Sekeh S R, Bahmani Mahmoud B, Mohammadi A, Rameshrad M. Investigation of the Anti-Inflammatory Effects of Sitagliptin in a Carrageenan-Induced Inflammatory Model in the Rat Foot. North Khorasan University of Medical Sciences 2026; 18 (1) :43-48
URL: http://journal.nkums.ac.ir/article-1-3349-en.html
URL: http://journal.nkums.ac.ir/article-1-3349-en.html
Fatemeh Ghofrani1 
, Bahram Bibak2 , Seyede Reyhaneh Ramezanzadeh Sekeh3 , Bahareh Bahmani Mahmoud4 , Ameneh Mohammadi5 , Maryam Rameshrad *6
, Bahram Bibak2 , Seyede Reyhaneh Ramezanzadeh Sekeh3 , Bahareh Bahmani Mahmoud4 , Ameneh Mohammadi5 , Maryam Rameshrad *6
1- Student Research Committee, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
2- Associate Professor, Department of Physiology, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
3- Assistant Professor, Department of Anatomy and Pathology, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
4- Department of Traditional Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
5- MSc in Phytochemistry, Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran
6- Associate Professor, Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran- Associate Professor, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran ,mrameshrad@gmail.com
2- Associate Professor, Department of Physiology, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
3- Assistant Professor, Department of Anatomy and Pathology, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
4- Department of Traditional Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
5- MSc in Phytochemistry, Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran
6- Associate Professor, Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran- Associate Professor, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran ,
Abstract: (40 Views)
Introduction: Inflammatory processes play the main background role in many diseases. One of the most common methods for investigating inflammation is the rat paw edema model. Sitagliptin is used as a blood sugar controller, and it can have anti-inflammatory properties. Therefore, this study was conducted to investigate this process.
Methods: In this study, rats (male Wistar weighing 180-200 grams) were selected. Doses of 5, 15, and 45 mg/kg of sitagliptin were evaluated. A group receiving solvent was considered a negative control, and another group received intraperitoneal indomethacin (2.5 mg/kg), a positive control. To induce edema, 100 microliters of carrageenan colloidal suspension (1%) were locally injected into the sole of the left paw of the rat. Paw volume was measured by calipers immediately before the carrageenan injection and then every hour after the injection until the fourth hour. The obtained measurements were calculated as the percentage increase in paw volume and compared with the values of the control group. Statistical analysis was performed using SPSS software (version 20).
Results: The results of this study showed that sitagliptin, compared to carrageenan, at doses of 5 and 45 mg/kg of rat body weight, led to a significant (P<0.001) decrease in the amount of edema in the paw of the animal, where mild to moderate neutrophil infiltration was observed. Slight edema in the dermis and a mild spongy appearance in the epidermis were also visible.
Conclusions: Sitagliptin, a dipeptidyl peptidase 4 inhibitor, could reduce the intensity of inflammation potentially improving and alleviating the complications of various diseases
Methods: In this study, rats (male Wistar weighing 180-200 grams) were selected. Doses of 5, 15, and 45 mg/kg of sitagliptin were evaluated. A group receiving solvent was considered a negative control, and another group received intraperitoneal indomethacin (2.5 mg/kg), a positive control. To induce edema, 100 microliters of carrageenan colloidal suspension (1%) were locally injected into the sole of the left paw of the rat. Paw volume was measured by calipers immediately before the carrageenan injection and then every hour after the injection until the fourth hour. The obtained measurements were calculated as the percentage increase in paw volume and compared with the values of the control group. Statistical analysis was performed using SPSS software (version 20).
Results: The results of this study showed that sitagliptin, compared to carrageenan, at doses of 5 and 45 mg/kg of rat body weight, led to a significant (P<0.001) decrease in the amount of edema in the paw of the animal, where mild to moderate neutrophil infiltration was observed. Slight edema in the dermis and a mild spongy appearance in the epidermis were also visible.
Conclusions: Sitagliptin, a dipeptidyl peptidase 4 inhibitor, could reduce the intensity of inflammation potentially improving and alleviating the complications of various diseases
Type of Study: Orginal Research |
Subject:
Basic Sciences
Received: 2025/07/15 | Accepted: 2025/11/29 | Published: 2026/03/29
Received: 2025/07/15 | Accepted: 2025/11/29 | Published: 2026/03/29
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