Volume 18, Issue 3 (Autumn 2026)
nkums 2026, 18(3): 43-51 |
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Akbari A A, Davari S A, Hajinezhad M R, Saadati D. Protective Effects of Coenzyme Q10 against Thioacetamide Oxidative Damage on Testicular Tissue and Liver and Kidney Biochemical Parameters in Male Wistar Rats. nkums 2026; 18 (3) :43-51
URL: http://journal.nkums.ac.ir/article-1-3426-en.html
URL: http://journal.nkums.ac.ir/article-1-3426-en.html
1- Doctor of Veterinary Medicine, Department of Pathobiology, Faculty of Veterinary Medicine, University of Zabol, Zabol, Iran
2- Assistant Professor, Department of Pathobiology, Faculty of Veterinary Medicine, University of Zabol, Zabol, Iran ,a.davari@uoz.ac.ir
3- Associate Professor, Department of Basic Sciences, Faculty of Veterinary Medicine, University of Zabol, Zabol, Iran
4- Associate Professor, Department of Food Hygiene, Faculty of Veterinary Medicine, University of Zabol, Zabol, Iran
2- Assistant Professor, Department of Pathobiology, Faculty of Veterinary Medicine, University of Zabol, Zabol, Iran ,
3- Associate Professor, Department of Basic Sciences, Faculty of Veterinary Medicine, University of Zabol, Zabol, Iran
4- Associate Professor, Department of Food Hygiene, Faculty of Veterinary Medicine, University of Zabol, Zabol, Iran
Abstract: (43 Views)
Introduction: Oxidative stress is a key factor in tissue damage and organ failure, underscoring the importance of identifying effective antioxidants. This study aimed to determine the protective properties of Coenzyme Q10 against thioacetamide-induced toxicity in testicular tissue and the biochemical parameters of the liver and kidneys.
Methods: In this experimental research, 20 male Wistar rats were divided into four groups. Group A (control); group B (thioacetamide, 200 mg/kg, intraperitoneal injection twice weekly); group C (Coenzyme Q10, 10 mg/kg/day via gavage); and group D (Coenzyme Q10, 10 mg/kg via gavage, plus thioacetamide, 200 mg/kg, intraperitoneal injection twice weekly). After 21 days, levels of alanine transaminase (ALT), aspartate transaminase (AST), blood urea nitrogen (BUN), serum creatinine, and malondialdehyde (MDA) were measured in the serum. Data were analyzed statistically by one-way analysis of variance (ANOVA) followed by Tukey's post hoc test. Additionally, testicular tissue was examined qualitatively for histopathological lesions.
Results: ALT, AST, and serum MDA levels increased significantly in group B, compared to the control group (P ≤ 0.001), whereas BUN and serum creatinine levels showed no significant changes (P ≥ 0.05). The histopathological examination revealed significant damage to the spermatogenic ducts in group B, while significant improvement was observed in group D.
Conclusion: Coenzyme Q10 may mitigate the toxic effects of thioacetamide on testicular, hepatic, and renal tissues, likely due to its potent antioxidant properties.
Methods: In this experimental research, 20 male Wistar rats were divided into four groups. Group A (control); group B (thioacetamide, 200 mg/kg, intraperitoneal injection twice weekly); group C (Coenzyme Q10, 10 mg/kg/day via gavage); and group D (Coenzyme Q10, 10 mg/kg via gavage, plus thioacetamide, 200 mg/kg, intraperitoneal injection twice weekly). After 21 days, levels of alanine transaminase (ALT), aspartate transaminase (AST), blood urea nitrogen (BUN), serum creatinine, and malondialdehyde (MDA) were measured in the serum. Data were analyzed statistically by one-way analysis of variance (ANOVA) followed by Tukey's post hoc test. Additionally, testicular tissue was examined qualitatively for histopathological lesions.
Results: ALT, AST, and serum MDA levels increased significantly in group B, compared to the control group (P ≤ 0.001), whereas BUN and serum creatinine levels showed no significant changes (P ≥ 0.05). The histopathological examination revealed significant damage to the spermatogenic ducts in group B, while significant improvement was observed in group D.
Conclusion: Coenzyme Q10 may mitigate the toxic effects of thioacetamide on testicular, hepatic, and renal tissues, likely due to its potent antioxidant properties.
Type of Study: Orginal Research |
Subject:
Basic Sciences
Received: 2025/10/12 | Accepted: 2026/05/3 | Published: 2026/09/29
Received: 2025/10/12 | Accepted: 2026/05/3 | Published: 2026/09/29
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