Journal of North Khorasan

Abstract Background & Objectives:In recent times the natural products obtained from organisms such as medicinal plants (secondary metabolites) are known as a powerful source to supplement therapy and prevention of porstate cancer and BPH. In this review article some of the famous and applicable natural products and medicinal plants used in clinic are discussed. The following information is dealing with the developments in the pharmacology and clinical trials of the known agents isolated from medicinal, as well as their suggested mechanisms. Material and Methods: This research was done based on the searching the keywords including Natural products BPH Prostate cancer anticancer Clinical trials, mechanism through the well-known databases from beginning to 2012. Results: In this review nine bioactive compounds isolated from nature and medicinal plants with considerable biological and pharmacological activities in treatment of cancer and benign hyperplasia of prostate are discussed. The main focuses are the clinical usage and biological effects with studying the probable mechanism of their action. Conclusion: During the past years many of these agents have been used in the treatment of the prostate cancer and BPH. Nine considerable bioactive structures are reported in this review. Today the potential for development of leads from natural sources and medicinal plants is growing dramatically, mainly in the area of anticancer investigations. The data prepared and described here are intended to be served as a reference tool to the natural products and chemistry specialists in order to expand the rational drug design.