Background & Objectives:Local pain due to propofol injection is a common side effect of propofol. Many methods have been introduced to reduce this pain. Combination of nitroglycerine and lidocaine is recomnded to reduce this pain . In this study, we aimed to compare the combination of nitroglycerine and lidocaine with lidocaine alone to reduce this pain of propofol injection in patients undergoing general anesthesia Material & Methods:In this double blind randomized clinical trial, 90 patients in three groups : 1- control group (placebo) 2- group(L) lidocaine 3- group LN: lidocaine + nitroglycerine. In control group, sterile water injected as placebo, in group l: lidocaine 2% with nitroglycerine 0.1 µ /kg was injected. Hemodynamic changes were measured during study. Pain and pain severity in these three groups were measured. Results:Hemodynamic changes, systolic blood pressure and diastolic blood pressure heart rate and saturation in this study were unchanged. Pain in the control group was 96.7%, that was more than group L(56.7%) and more than group LN(6.7%) (p<0.001). Severity of pain in group LN was less than group L(P<0.001). Sever pain was not seen in group LN. Conclusions :Both Lidocaine and lidocaine +nitroglycerine reduced pain of propofol injection while combiniation of lidocaine and nitroglycerine has more efficacy and less pain so it can be used for reducing pain of propofol injection.