Background & objectives: This study was aimed in order to assessment of pregnancy rate and prognostic factor in success rate of oocyte donated IVF cycles in women who candidated for oocyte donated cycle. Methods & Material: This was a prospective study of 100 women who because of different reasons such as premature ovarian failure , genetic problem and decreased ovarian reserve were candidate for IVF cycle with oocyte donation. Prognostic factors including age of donor and recipient, BMI of both, number of oocyte retrieved and embryos, endometrial thickness and emotional state of recipients and pregnancy rate were assessed. Results: in this study pregnancy rate was 59%. Between different parameters BMI of both donor and recipients has statistically significant negative correlation with IVF successes rate. (CI=95% p< 0.05)Younger age of donor and recipient has positive but not statistically significant effect on pregnancy rate. With frequent psychiatric consultation all recipients have a good emotional state and completely accepted the baby as her own child. Conclusion: IVF with donated oocyte is a highly successful treatment in women who are candidate for donation. Lower BMI in addition to health status has positive effect on pregnancy rate. Lower age pregnancy for both donor and recipient accompanied with better prognosis.