Seizure resulted from tramadol can cause bilateral joint dislocation. This study is a rare case report that represents fracture and dislocation of right shoulder due to seizure in a 32years old man that had consumed a 300mg single dose of tramadol. He did not have any history of previous seizure or spontaneous dislocation of the shoulder. The right shoulder radiography and MRI demonstrated dislocation of the head of humerus with fracture of its greater tuberosity.  Seizure as a side effects of therapeutic dose of tramadol, can occur during sleep, resulting to serious complications

Keywords: Tramadol, shoulder dislocation, seizure