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Showing 6 results for Afshari
Evaluation the effect of water extract of Alpinia galangal L. on inhibition of the HT-29 colorectal cancer cell Lines and rat fibroplast non-cancer cell line (L929).
J Tavakol Afshari, M Haj Zade, M Barati,
Volume 1, Issue 1 (Autumn2008 2008)
Abstract
Introduction: In new studies many anticancer compounds have been introduced from Alpinia galangal L. Anticancer effects of these compounds are from free radicals removal  and inhibition of enzyme activities and cell cytotoxicity. The purpose of present study is evaluation the effect of water extract of Alpinia galangal L on HT-29 Cancer Cell Lines and rat fibroplast (L 929) in vitro.
Methods: Water extract of Alpinia galangal was placed in plates with cultured cells. morphological information (cell shape, granulocytic cell count and adhesion to the cell surface) were collected With inverted microscope for two cell lines HT-29 AND L 929 in vitro. In other part of study, cultured cells from each line were evaluated with MTT for three days and present of living cells in each of two cell lines and for each concentration of extract were calculated in Mean ± SD , and recorded. The results were evaluated with Instate and SPSS, ANOVA one-way and Tukey-Kramer or T-test software. When P<0.05 , differences are considered significant.
Results: Water extract of Alpinia galangal L in using concentrations inhibits the growth of each two line cells. The inhibitory effects of this extract on L929 cells is similar to or higher than inhibition effects on colon cancer cells; IC50 is 1500 µg/ml for healthy and cancer cell lines. In each two cell lines the percentage of Living cells will be reduced with increasing the concentration.
Conclusion: The results of this study showed that water extract of Alpinia galangal L had cytotoxic effects on cell lines HT-29 and L929. Therefor in using of water extract of Alpinia galangal L for treatment of cancer , it is better to use other kinds of Alpinia galangal L extracts that have cytotoxic effects on cancer cell lines.
 
Psychometric properties of the healthful eating belief scales for type 2 diabetics
H Rohani , Aa Eslami , M Raei , H Tavakoli Ghouchani , A Afshari ,
Volume 6, Issue 2 (Summer 2014 2014)
Abstract

Abstract Background & Objectives: Moderate changes in diet have been shown to prevent or delay complications of type 2 diabetes. Understanding beliefs about healthful eating among persons at risk for diabetes may help to develop interventions to change these beliefs as a mechanism for changing dietary behaviors in this population. Therefore objective of this study is to examine the validity and reliability of Theory of Planned Behavior (TPB) scales for healthful eating for persons with diabetes. Material & Methods: Cross-sectional study was conducted in Semirom diabetes clinic, using a self-administered questionnaire. Participants were 142 adults who had not complications of diabetes. Variables measured were attitude, subjective norm, perceived behavioral control, and intention to eat a healthful diet. Construct validity was assessed with factor analyses. Reliability of the scales was assessed with Cronbach alpha and a 2-month test-retest. Results: Factor analysis loadings were greater than 0.4. Cronbach alphas for attitude, subjective norm, perceived behavioral control, and intention were .92, .91, .91 and .90, respectively. Factor analysis revealed that the constructs fit well for predicting intention to eat a healthful diet. Test-retest revealed 2-month stability of the scales. Conclusions: Questionnaire for measuring TPB constructs attitude, subjective norm, perceived behavioral control were valid and reliable for use with adults with diabetes.


Evaluation of prognostic factor in IVF cycle with oocyte donation
Z Heidar , M Mirzamoradi , A Afshari, M Pourhoseingholi ,
Volume 7, Issue 2 (9-2015)
Abstract

Background & objectives: This study was aimed in order to assessment of pregnancy rate and prognostic factor in success rate of oocyte donated IVF cycles in women who candidated for oocyte donated cycle. Methods & Material: This was a prospective study of 100 women who because of different reasons such as premature ovarian failure , genetic problem and decreased ovarian reserve were candidate for IVF cycle with oocyte donation. Prognostic factors including age of donor and recipient, BMI of both, number of oocyte retrieved and embryos, endometrial thickness and emotional state of recipients and pregnancy rate were assessed. Results: in this study pregnancy rate was 59%. Between different parameters BMI of both donor and recipients has statistically significant negative correlation with IVF successes rate. (CI=95% p< 0.05)Younger age of donor and recipient has positive but not statistically significant effect on pregnancy rate. With frequent psychiatric consultation all recipients have a good emotional state and completely accepted the baby as her own child. Conclusion: IVF with donated oocyte is a highly successful treatment in women who are candidate for donation. Lower BMI in addition to health status has positive effect on pregnancy rate. Lower age pregnancy for both donor and recipient accompanied with better prognosis.


Report of a Case of Immunoglobulin A Nephropathy in a Patient Without a Family History of Kidney Disease
Amir Bigdeli, Marzieh Ghorbani Moghadam , Maliheh Afsharian ,
Volume 12, Issue 2 (10-2020)
Abstract
Introduction: IgA Nephropathy is the most common form of glomerulonephritis and the major cause of end-stage renal disease. Gross or microscopic hematuria is a common symptom of hematuria and occurs in less than 5% to 10% of patients with IGM with rapidly progressive glomerulonephritis. The aim of this study was to investigate the diagnostic biomarkers of this disease after biopsy.
Methods: IgA (N) Nephropathy is the most common glomerulonephritis in the world and is currently recognized as an important end-stage renal disease (ESRD). Hypertension, proteinuria greater than 1 g / day, and severe lesions in primary renal biopsies such as crescent and interstitial fibrosis are the major predictors of progression to ESRD. Despite its prevalence and clinical significance, there is no consensus for treating patients with risk factors for worse prognosis. Our aim is to describe cases of crescentic IgA N and emphasize the efficacy of immunosuppressive therapy here.
Results: This is a case-control study of the physiological and pathologic features of a patient with clinical, radiologic, and treatment modalities of a patient with immunoglobulin A nephropathy without a history of renal disease.
Conclusions: IgA Nephropathy, first identified nearly four decades ago as one of the types of kidney disease, is one of the most common causes of primary glomerulonephritis in developing countries and is now one of the major causes (End - stage renal disease (ESRD).

Evaluation of the Students’ Drug Use Intention based on the Theory of Planned Behavior Model (TPB) in North Khorasan University of Medical Sciences
Hamid Tavakkoli Ghouchani, Seyed Kaveh Hojjat, Alireza Afshari-Safavi, Faezeh Kaviyani, Fatemeh Shayanfar,
Volume 16, Issue 2 (Summer 2024)
Abstract
Introduction: Considering the high prevalence of drug use in Iran and the need to pay attention to this issue in educational environments, it is important to identify the underlying factors to plan preventive measures. Therefore, the aim of the present study was to investigate the intention of drug abuse in students of North Khorasan University of Medical Sciences.
Method: The current cross-sectional study was conducted using a descriptive-analytical design. The statistical population consisted of students of North Khorasan University of Medical Sciences in 2022. The samples (n=237) were selected using a stratified sampling method. The tool for collecting information was the questionnaire of Mirzaei et al., whose validity and reliability were already confirmed. Data analysis was done in SPSS24 software and by Chi-square, independent t, Mann-Whitney, and logistic regression models.
Results: The mean age of the participants was 23.75±3.86 (19-45) years. The history of smoking, alcohol use, and opium use was 28.3%, 23.6%, and 8%, respectively. Besides, 25.8% of the participants had a history of using other substances, including hashish, crack, heroin, ecstasy, amphetamine, and LSD. Based on the results of this study, the relationship between behavioral intention and attitude, abstract norms, and perceived behavioral control was statistically significant )P<0.05). Moreover, a significant relationship was observed between drug use and male gender, smoking, and having friends using drugs.
Conclusion: Considering that attitude was a stronger predictor of behavioral intention, it seems that the implementation of appropriate educational programs can be an effective measure to raise students’ awareness in this regard.

In vitro evaluation of the combined effect of different concentrations of the calcium hydroxide and ethanolic extract of Allium hirtifolium on the oral pathogen (Enterococcus faecalis)
Shaghayegh Mohebali, Vahideh Motamedosanaye, Samaneh Molazadeh, Parastoo Zarghami Moghaddam, Alireza Afshari-Safavi,
Volume 16, Issue 3 (Autumn 2024)
Abstract
Introduction: One of the important issues in root canal treatment is the elimination of the microorganisms in the root canal before obturation. This study aimed to experimentally investigate the combined effects of ethanol extract of Allium hirtifolium (shallot) and calcium hydroxide on the biofilm structure of the resistant bacterium Enterococcus faecalis.
Method: Dried Allium hirtifolium was extracted with ethanol. Various concentrations (0-20-40-50-60-80-100 mg/ml) of the extract and calcium hydroxide were prepared. Antibacterial effects of these compounds were evaluated against Enterococcus faecalis using disc-diffusion, well-diffusion, and biofilm formation inhibition assays, along with optical absorption measurements.
Results: The results showed that in disc-diffusion and well-diffusion methods, the highest antibacterial effects were observed in the positive control group (antibiotics amoxicillin and co-amoxiclav), 100 mg/ml calcium hydroxide, and combined concentrations of calcium hydroxide and Allium hirtifolium (80/20, 60/40 and 50/50 mg/ml). Other concentrations of these compounds did not affect Enterococcus faecalis. Regarding biofilm formation, the study revealed that the ability of Enterococcus faecalis to form biofilm was weak at concentrations of 100, 80, and 60 mg/ml of calcium hydroxide, while other concentrations of the studied substances showed average inhibition.
Conclusion: The present study revealed that in disc diffusion and well-diffusion methods, ethanol extract of Allium hirtifolium alone or in combination with calcium hydroxide did not significantly inhibit the growth of Enterococcus faecalis, while calcium hydroxide exhibited the highest (100%) antibacterial effect

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