Journal of North Khorasan

Abstract Background and objectives: Quality of life can be considered as a marker of the quality of health care and is a part of the patient's treatment plan. Its measurement in type 2 diabetic patients provides useful information to health authorities. Material and Methods: This study is a descriptive- analytic cross – sectional study that has attempted to measure the quality of life in diabetic patients in Chaharmahal & Bakhteyari Province. The number of patients was 254 and they were selected randomly in two stages. Data were collected through questionnaires with acceptable validity and reliability measures. The data were analysed with software STATA 9 using independent t-test, ANOVA, Chi-square and multiple linear regression. Results: The mean total score of quality of life was 122.8 out of 184 (SD: 1.1) in this study. 27.6% of the patients had favourable quality of life, 67.3% had rather favourable and 5.1% had unfavourable quality of life. The most important factors that determine quality of life in diabetic patients include satisfaction with health insurance, a history of hospitalization due to diabetes, a history of more than 10 years of diabetes, control of hypertension, micro- and macrovascular complications of diabetes, sight dimness and sleep disorder. Conclusions: Based on an accurate recognition of quality of life and its determinants in diabetic patients, a background has been provided for policymakers, planners, researchers, physicians and nurses working in a diabetic management tearn.

Abstract Background & Objectives: Sensory deprivation is one of the complications threatening the comatose patients. Sensory stimulation is a treatment that awakes the brain's reticular activating system, which helps brain re-organization. This study aimed to investigate the impact of familiar sensory stimulation on level of Consciousness in patients with head injury in ICU. Material & Methods: This clinical trial was conducted on 60 patients with head injury in ICUs of Mashhad Emdadi Hospital. Intervention was the presence of family members and provides sensory stimulation in first 6 days of admission. Patients consciousness checked on GCS score on the first day and sixth and findings was analyzed with the SPSS 11.5. Results: According to the non-normal distribution of the GCS, the Mann-Whitney test was used. The results of this test showed that the GCS in first day were homogeneous in two groups (P=0/402). Increase of GCS on the sixth day in the intervention group was more statistically significant than the control group (P=0/002). Conclusion: Early sensory stimulation is increase consciences in patients with brain injury. Revising in visiting policy in intensive care unit can be appropriate to provide positive effects of family presence on patient.

Background& objectives: Accumulation of free oxygen radicals leads to the oxidative tension. This tension will be able to change the enzyme activity, gene expression, calcium release from intracellular deposits on the membrane structure, cell growth, and death. Plants are rich in the case of antioxidant compounds which will be able to  reduce the risk of some chronic diseases such as cancer, heart disease and stroke by protection of cells and increasing the plasma antioxidant power. This study aimed to evaluate the antioxidant activity and cytotoxicity of methanol extract of the Eremostachys labiosiformis (Popov) Knorring plant.

Materials and Methods: Methanol extracts were obtained from E.labiosiformis plant by maceration method following the collection, drying and powdering. The antioxidant activity and cytotoxicity effect were assessed by free radical scavenging method (DPPH) and MTT (on Vero cell lines), respectively.

Results: The antioxidant capacity of E.labiosiformis methanol extract was0/392 mg/ml. Cytotoxic effect (CC50) during different times of 24, 48 and 72 hours was also 1329/16 µg/ml, 1360/25 µg/ml and 1159/71 µg/ml, respectively.

Conclusion: The comparison results of E.labiosiformis antioxidant properties with ascorbic acid showed that this plant has a good free radical scavenging activity in comparison with the other similar plants. In the case of toxicity assessment, it was shown that the methanol extract of this plant can be safe for use in therapy. However, using the other cell lines as well as in vivo studies are recommended for a definitive conclusion.