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Showing 2 results for Motamedosanaye
Comparative analysis of CD105 and bcl2 expression in radicular cyst, dentigerous cyst, OKC and ameloblastoma by immunohistochemistry
A Gholami, V Motamedosanaye , A Bijani ,
Volume 7, Issue 3 (1-2016)
Abstract

Background & Objectives:The purpose of this study is to evaluate the immunohistochemical expression of CD105 and Bcl2 in radicular cyst, dentigerous cyst, OKC and ameloblastoma.

Material and methods: In this analytical retrospective study, 15 samples of radicular cyst, 15 dentigerous cyst, 15 OKC and 5 samples of ameloblastoma were selected. The samples were deparafinized and antigens were retrieved. Immunohistochemistry technique was applied for evaluation of CD105 and bcl2. Findings were analyzed by SPSS17 software. Comparative analysis of data was performed by using the Mann-Whitney T-test for two independent samples. A p value of less than 0.05 was considered to be statistically significant.

Results: The mean value of bcl2 expression in radicular, dentigerous, OKC and ameloblastma were  78,71.13, 48 and 45 respectively. There is no significant difference between OKC and ameloblastoma(p >0.05). The percentage of CD105 positive vessels was higher in radicular cyst and decreased in dentigerous cyst, OKC and ameloblastoma.

Conclusion: The higher expression of bcl2 in OKC and ameloblastoma can explain the more aggressive clinical behavior of these lesions, although, angiogenesis has no impression on it.

Keywords: radicular cyst, dentigerus cyst, OKC, ameloblastoma, CD105 and bcl2,Immunohistochemistry.


In vitro evaluation of the combined effect of different concentrations of the calcium hydroxide and ethanolic extract of Allium hirtifolium on the oral pathogen (Enterococcus faecalis)
Shaghayegh Mohebali, Vahideh Motamedosanaye, Samaneh Molazadeh, Parastoo Zarghami Moghaddam, Alireza Afshari-Safavi,
Volume 16, Issue 3 (Autumn 2024)
Abstract
Introduction: One of the important issues in root canal treatment is the elimination of the microorganisms in the root canal before obturation. This study aimed to experimentally investigate the combined effects of ethanol extract of Allium hirtifolium (shallot) and calcium hydroxide on the biofilm structure of the resistant bacterium Enterococcus faecalis.
Method: Dried Allium hirtifolium was extracted with ethanol. Various concentrations (0-20-40-50-60-80-100 mg/ml) of the extract and calcium hydroxide were prepared. Antibacterial effects of these compounds were evaluated against Enterococcus faecalis using disc-diffusion, well-diffusion, and biofilm formation inhibition assays, along with optical absorption measurements.
Results: The results showed that in disc-diffusion and well-diffusion methods, the highest antibacterial effects were observed in the positive control group (antibiotics amoxicillin and co-amoxiclav), 100 mg/ml calcium hydroxide, and combined concentrations of calcium hydroxide and Allium hirtifolium (80/20, 60/40 and 50/50 mg/ml). Other concentrations of these compounds did not affect Enterococcus faecalis. Regarding biofilm formation, the study revealed that the ability of Enterococcus faecalis to form biofilm was weak at concentrations of 100, 80, and 60 mg/ml of calcium hydroxide, while other concentrations of the studied substances showed average inhibition.
Conclusion: The present study revealed that in disc diffusion and well-diffusion methods, ethanol extract of Allium hirtifolium alone or in combination with calcium hydroxide did not significantly inhibit the growth of Enterococcus faecalis, while calcium hydroxide exhibited the highest (100%) antibacterial effect

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