Showing 11 results for Rezaeian
A Rezaeian, H *, Boskabadi , Sr Mazlom,
Volume 4, Issue 3 (Autumn2012 2012)
Abstract
Abstract Background & objectives: Prematurity is the major cause of neonatal mortality, so this study aimed to determine the perinatal factors related to the premature infant’s mortality. Material & Method: Sample of records of this historical cohort study, was premature infants hospitalized in the Qhaem hospital intensive care unit, since 2007 to 2010. Two hundred cases were randomly selected. After the sample loss, 172 files precisely were studied from admission to discharge. Data were collected using a validated researcher made questionnaire, analyzed with SPSS19th, and presented with descriptive statistics, Fisher’s exact test, chi-square and T tests. Results: From 172 neonates based on death or alive until 28th day after birth, 54 and 118 were included in the case and control groups, respectively. Birth weight and gestational age of the subjects, were 1549.54(±635.42) g and 31.46 (±3.35) weeks, respectively. Antenatal taking of nitroglycerin, magnesium sulfate, methyldopa, hydralazine and chronic use of insulin were not significantly deferent in the two groups (P>0.05), and had Odds ratio more than 1. Diabetes, preeclampsia, maternal Rh and blood group, were significantly deferent between the two groups (P<0.05). In the birth room crying, breathing, cyanosis, tonicity, cord status, and a history of neonatal resuscitation (p<0.001) and neonatal clinical findings at the NICU admission time including apnea, bradycardia, gasping, hydrops, ascites, and IUGR (p<0.005) were significantly deferent between the two groups. Conclusion: Some of the maternal and neonatal perinatal factors could affect the premature neonates' mortality. Considering these factors could be effective in determining at risk neonates and providing factors in reducing mortality
M Haresabadi , M Tabatabaeichehr , S.m Rezaeian , M Mehrabi Bardar , S Khakshor Fariman ,
Volume 5, Issue 5 (Monogarph 2013 2014)
Abstract
Abstract Background & Objectives: stress is one of the problems that can interfere with midwifery clinical training and influence their efficiency. Continuous investigation into educational stressors and managing them is essential for quality improvement of clinical education. This study aimed to identify the stressors of clinical training in midwifery students of North Khorasan University of Medical Scieneces (2011). Materials & Methods: In this cross sectional- analytic study 51 students in the second academic year were selected. Data were collected through a questionnaire 72-item containing eight domains. Data were analyzed with SPSS (Ver. 16) software. Results: 60.5% of students experienced average tension, and 25.6% relatively high tension. Students reported the “communication with patient” as the main source of tension while other domains were reported as causing average tension. Conclusion: since tension can impose adverse effects on clinical education, it is recommended to reduce it through techniques such as raising awareness about the sources of tension and increasing technical and professional knowledge.
A Rezaeian , A Niknejad Jalali , Hr Behnam Vashani, F Ashrafzadeh , M Rezaeian ,
Volume 6, Issue 3 (Autumn 2014 2014)
Abstract
Abstract Background & objectives: Due to repeated environmental disparities nursery children are at risk for developmental delay. This study aimed to determine the effect of an evidence-based care package on infant fine motor development. Material & Methods: In this clinical trial at the Ali Asghar (AS) nursery of Mashhad, an evidence-based care package was utilized. Fifty babies with the age of 1-12 month eligible for inclusion criterion were randomly divided in to the intervention (25 infant) and control (25 infant) groups. Then the care package was administered for the intervention group, three times a week for 8 weeks (24 sessions of two hours). Fine motor developmental age of the children was assessed by Denver-II, before the intervention, 6 and 8 weeks after the intervention, and the resulting data were analyzed using independent t-test, Mann-Whitney U and repeated measures. Results: The mean age of the sample was 20.64±14.62 week, consisting of 32% female and 68% male. The mean of the fine motor age respectively were 23.5±14.2 and 21.1±17.7 in the intervention group and control group (P>0.05). After 6 weeks implementing the care package, the mean of the fine motor age in the intervention group (33.3±14.9) and control group (23.3±14.4) showed a statistically significant difference (p-0.008). Two weeks later (8th weeks) this value in the intervention group (35.8±13.4) and control group (24.9±13.4) showed a statistically significant difference (p<0.001). Conclusion: Six weeks intervention by this evidence-based care package is effective on the infant's fine motor development. This effect was approved 2 weeks later.
Ali Khakshour, Mostafa Eghdami, Anoosh Azarfar, Yalda Ravanshad, Aramesh Rezaeian,
Volume 11, Issue 3 (12-2019)
Abstract
Introduction: Self- Medication is a major problem in the treatment cycle. The purpose of this study was to investigate the frequency and factors affecting self-medication in children were referred to the Sheikh Hospital's clinic of Mashhad.
Methods: This cross-sectional study was carried out on 198 children who were referred to the Sheikh Hospital's clinic. The sampling was according to census method. The data-gathering tool was a researcher-made questionnaire for parents. Data analysis was performed using SPSS20 software and descriptive statistics.
Results: Of the 198 cases studied, 161 (81.6%) of the parents had self-medication for their child. The most commonly reported cases of self-medication were colds (64.1%), fever (60.1%) and digestive diseases (17.7%). Antipyretics (66.2%), common cold drugs (57.6%), anti-cough drugs (30.8%), and antibiotics (24.7%) were the most commonly used drugs. The lack of access or expensive visit of the physician (60%), availability and easy access to drugs (60%), and previous self-medication experience (50%) were the most important factors influencing the self-medication. There was a significant relationship between father's education (P = 0.006), mother's education (P = 0.001) and family income (P = 0.03) with self-medication; and in very high or very low education, or low family income self-medication increased.
Conclusions: Preventive measures seem to be necessary. In this regard, provision of training programs to inform the community about the dangers of self-medication, as well as adoption of preventive measures from the relevant institutions could be suggested.
Zohreh Abbasi, Mahbobeh Hakime Najaf Abad, Reza Ganji, Raheleh Asali, Seyed Hamid Nabavi, Salar Poorbarat, Seyedeh Mahboobeh Rezaeian,
Volume 12, Issue 4 (2-2021)
Abstract
Introduction: Osteoarthritis is the most common articular disease and functional disorders is one of the symptoms. The purpose of this study was to evaluate the effect of massage on knee functional problems in elderly women with osteoarthritis.
Methods: The statistical population consisted of 58 elderly women with mild to moderate osteoarthritis referred to Rheumatology Clinic of Bojnurd city using a cross-sectional clinical trial the sampling method was purposive and the patients were divided into control group and comparative group. After the day of diagnosis, during the intervention seven phase of intervention massages was performed on the knees fifteen minutes each day for one week with effleurage method. In intervention group standard treatments (100 mg Diclofenac) were used. Statistical analysis was performed using SPSS 16 software, and paired t-test, paired and independent t-tests, central and dispersion indices were calculated.
Results: In response to the main purpose of the study, "Determination of mean pain in older women before and after intervention" in both groups showed that knee massage reduced pain severity which revealed there was a significant difference.
Conclusions: Although there are many techniques which can be effective on functional disorders but performing massage techniques such as massage therapy are more effective for reduction of functional disorders due to availability, cheapness, patients interests, informality, absence of complications and efficiency.
Saghar Delshad, Ali Yaghoubi, Najme Rezaeian,
Volume 12, Issue 4 (2-2021)
Abstract
Introduction: Aging is associated with muscle atrophy or sarcopenia. Autophagy is a process that reduces muscle atrophy; however, the efficiency of this process decreases with age. Exercise improves sarcopenia and the process of autophagy by activating signaling pathways. Therefore, the aim of the present study was to investigate the effect of moderate-intensity continuous training (MICT) on protein levels of ULK1, beclin1, Sestrins2, and AMPK phosphorylation in skeletal muscle of elderly male rats.
Methods: Twenty elderly male Wistar rats (18 months years old) were randomly divided into two groups of 1) MCIT 2) control (10 ones in each). MICT protocol included eight weeks of running on treadmill at intensity of 65-70 percentage of Vo2max with speed of 18-29 meter per minute for 25-40 minutes per sessions and five sessions per week. Muscle tissue samples were taken from gastrocnemius muscle at 48 hours after the last training session. Independent t-test was used to analyze the data and P value <0.05 considered significant.
Results: Beclin1 protein levels were significantly increased in the MICT group compared to the control group (P = 0.001). However, the protein levels of ULK1, Sestrins2 and p-AMPK in the MICT group did not change significantly compared to the control group (P > 0.05).
Conclusions: It seems that MICT is not a suitable training method to activate autophagic pathways and subsequently improve the effects of aging in the skeletal muscles of elderly rats.
Maryam Karimi, Mahtab Moazzami, Najmeh Rezaeian,
Volume 13, Issue 1 (6-2021)
Abstract
Introduction: Multiple Sclerosis (MS) is an autoimmune, inflammatory and chronic disease that occurs as myelin damage and destruction in the white matter of the brain, spinal cord, and optic nerves and causes functional problems in the patient. The purpose of this study was to evaluate the effect of 8- week core stability training on some of functional indices in women with multiple sclerosis.
Methods: The study samples were 24 women with MS (25 to 40 years) in Bojourd with the EDSS level of disability of 2 to 5. Patients were randomly-purposefully divided into 2 groups: core stability training group (N = 12) and control group (N = 12) groups. Exercise group carried out an 8- week core stability exercise program for 30 to 40 min 3 times/week. During this time, the control group did not have any regular physical activity. Timed Up and Go test (TUG) was used to assessment of balance. In addition, Fatigue Severity Scale (FSS) questionnaire and One- Repetition Maximum (1RM) were used to evaluate fatigue and muscle strength of the two groups before and after training. Data were analyzed by covariance test with SPSS software at (P < 0.05).
Results: According to the results of covariance test, performing eight week of core stability training was associated with a significant increase in balance (P = 0.000), upper body muscle strength(P = 0.000), lower body muscle strength (P = 0.014) and reduced fatigue(P = 0.000).
Conclusions: According to the results of this study, performing core stability training can improve functional indices (balance, muscle strength and fatigue of people with MS. Therefore, these exercises can be used as an effective exercise activity in patients with multiple sclerosis for rehabilitation.
Hossein Kamali, Elham Khodaverdi, Nazanin Jafarzadeh, , Seyedeh Nesa Rezaeian Shiadeh, Farzin Hadizadeh,
Volume 15, Issue 2 (Summer 2023)
Abstract
Introduction: The present study aimed to extend a novel vehicle for sustained delivery of risperidone to improve schizophrenia therapy. Risperidone is used as an anti-psychotic drug to treat various psychological conditions. Lipid liquid crystal (LLC) gel containing various lipids, solvents, and stabilizers turns into a sustain-release gel in contact with the aqueous medium.
Method: Glycerol monooleate (GMO), glycerol dioleate (GDO), and glycerol trioleate (GTO) alongside several ratios of phosphatidylcholine (PC) to oil and N-methyl-2-pyrrolidone (NMP) solvent percent (w/w %) were assessed for initial burst release (IBR) for LLC. Some In-vitro evaluations, pharmacokinetics assessments, and histopathological studies were done to gain optimal formulation.
Results: the GDO-based LLC showed lower IBR in comparison to other glycerol-based formulations. Pharmacokinetic data revealed that GDO at PC:oil = 2.2:1 and NMP = 30% made a sustained release for two months. Risperdal CONSTA® can reach the required therapeutic levels after 2–3 weeks; however, over the lag period, co-administration of oral risperidone is essential. The histopathology results indicated approximately no side effects in rabbits.
Conclusion: This study confirms the great potential of GDO-based LLC in comparison to Risperdal CONSTA®. Furthermore, the results showed that a single injection of GDO-based formulations could maintain drug release in both in-vitro and in-vivo for two months in the therapeutic range.
Hossein Kamali, Elham Khodaverdi, Hamidreza Boujaran, Seyed Hojat Hosseini, Seyedeh Nesa Rezaeian Shiadeh, Farzin Hadizadeh,
Volume 15, Issue 3 (Autumn 2023)
Abstract
Introduction: Risperidone is a highly effective medicine in patients with mental disorders. Since maintaining blood concentrations of risperidone within the therapeutic index is pivotal during treatment, these patients should receive medication daily and continuously.
Method: In this study, an optimal lipid liquid crystal was designed according to the maximum release for 60 days based on different ratios of phosphatidylcholine (PC) to sorbitan monooleate (PC:SMO), tween 80 (w/w%), and tocopherol acetate (w/w%) using Design Expert software with the Central Composite Design (CCD) method. Release evaluations were conducted in vitro to compare the effects of lipid liquid crystal and Risperdal CONSTA®. The structure evaluation was also tested using polarized electron microscopy and in vitro assessment via cell culture.
Results: The optimal formulation was selected based on the maximum release (100%) of the drug obtained within 2 months with a PC: SMO ratio of 58.6%, tween 0.82% (w/w), and tocopherol acetate 3.6% (w/w). A hexagonal mesophase with a dihedral structure was observed in the liquid crystal structure. No toxicity was observed in the cell culture test.
Conclusion: The comparison of the results of in vitro studies of the liquid crystal formulation containing risperidone and the commercial formulation, Risperdal CONSTA®, showed that the liquid crystal system provides better and more uniform drug release for 60 days. Therefore, it can increase patient compliance and ease the problems of oral administration
Seyede Malihe Seyedi, Leila Hosseini, Seyed Kaveh Hojjat, Mina Norozi Khalili, Nahid Rezaeian, Sanaz Asadian,
Volume 16, Issue 3 (Autumn 2024)
Abstract
Introduction: Opium addiction is one of the most significant problems in Iran. This study investigates demographic information of opium-addicted patients undergoing maintenance treatment in Bojnurd addiction treatment centers. This study aims to identify high-risk groups and those who need therapeutic and psychosocial interventions to maintain treatments.
Method: This cross-sectional study was conducted from 2016 to 2021 on 300 addicted patients referring to Bojnurd addiction treatment centers. These patients participated in the opioid maintenance treatment program for at least six months. The investigation utilized a checklist of demographic information and examined the files of addicted people undergoing maintenance treatment in eight addiction treatment centers in the city. The data were analyzed in SPSS23 software using the Chi-square statistical test.
Results: The mean age (standard deviation) of the participants was 52.17±14.13 years. Besides, 76.6% of the participants were male, 70.0% resided in the city, and 73.6% were married. The majority of the participants had a primary education level and were self-employed. Opium juice was the most consumed substance, and smoking was the most common method of use.
Conclusion: It appears that married and middle-aged individuals constitute the largest population undergoing maintenance treatment in Bojnurd city. The high frequency of individuals with low or no literacy in the studied population underscores the importance of education.
Mohammad Mostafa Rezvani, Najmeh Rezaeian, Sadegh Cheragh Birjandi, Najmeh Sadat Shojaeian, Mostafa Teimoury Kharvi,
Volume 17, Issue 2 (Summer 2025)
Abstract
Introduction: Rho-Associated Protein Kinase (ROCK) is one of the members of serine-threonine protein kinases family playing a major role in the regulation of glucose metabolism and insulin sensitivity. The present study aimed to assess the effect of eight weeks of combined aerobic and resistance training on adipose tissue levels of ROCKs protein, insulin, fast blood sugar (FBS), insulin resistance index, and weight in aged female rats.
Method: A total of 22 rats (24-28 weeks old, 262.5±15.10 gr) were randomly assigned to two groups of experimental and control (11 ones in each). Rats in experimental group participated in eight weeks of combined aerobic (running on treadmill at intensity of 40%-60% of maximum velocity, 60 minutes) and resistance training (15 times of climbing on ladder at intensity of 40%-60% of maximum workload with 1 minute of rest interval, 45 minutes), five days per week. All rats were dissected after the last training session, and the investigated indicators were evaluated.
Results: Eight weeks of combined training resulted in significant increases in adipose tissue levels of ROCK1 (P=0.000) and ROCK2 (P=0.001), apart from significant decreases in FBS (P=0.001) and body weight (P=0.001) in the experimental compared to the control group. According to the paired t-test, weight decreased in experimental group in post-test compared to pre-test (P=0.004).
Conclusion: Although glucose uptake improved following eight weeks of combined aerobic and resistance training in old female rats, it seems that the increases in adipose tissue levels of ROCK proteins could not contribute to improving insulin sensitivity in response to exercise training.
