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Showing 5 results for Insulin Resistance
The Effect of resistance training on serum levels of RBP-4 and insulin resistance index in type 2 diabetic male rats
N Ramezani , Aa Gaiini , S Choobineh , Mr Kordi , K Baesi ,
Volume 9, Issue 2 (10-2017)
Abstract
Background & objectives:Diabetesis one of the most common metabolic diseaseswhich is characterized by hyperglycemia and failure of endogenous insulin.Levels of serum retinol-binding protein 4(RBP4) as an adipokin increase in insulin resistant or type 2 diabetic patientsreferring to its role in regulation of insulin function and glucose metabolism. The present study was designed to investigate the effect of resistance training on serum levels of RBP4 and insulin resistance (IR) index in type II diabetic male wistar rats.
Materials and Methods:Male 8-week-old Wistar rats were randomly assigned as study samples. Diabetes was inducedby intra peritoneal injection nicotinamid and streptozotocin. Five days after injection, blood glucose was measured and the rats with fasting glucose levels between 400-126 mg/dl, were considered as diabetic rats. Based on homogeneous body weight,rats were randomly categorizedinto two control and resistance training groups. Onemonthafter inducing diabetes, rats in the training group carried out an eight-week exercise program on a step ladder, whereas control group remained sedentary in their cages. The levels of the serum glucose, insulin, RBP4, and insulin resistance index (HOMA-IR) wereassessed.
Results:Serum concentration of RBP4[(57/3±9 to 70/9±12)(ng/dl),(p=0/007)], glucose[(234/8±36 to 324/5±16)(mg/dl), (p=0/001)], insulin[(5/5±0/8 to 6/7±0/66)( µmol//l),(p=0/002)], insulin resistance index[(0/3±0/11 to 0/2±0/18)( HOMA-IR), (p=0/002)] were significantly decreased in the training group in comparison with the control group.
Conclusions:The present study showed that resistance training could decrease glucose, insulin, and RBP4 level and improves insulin resistance in rats with type 2 diabetes.Therefore,it seems that this type of training can also be appropriate in patients with type 2 diabetes.

Evaluation of the Effect of Erynjium Alcoholic Extract on Increasing Insulin Sensitivity: By Evaluating Hyperglycemia and Dyslipidemia in an Animal Model of Insulin Resistance
Reza Taghipour, Ali Zaree Mahmoudabadi, Zohreh Jangravi, Hamidreza Javadi, Mohadeseh Rashedi Osqueei, Naser Mousavi, Mohammad Raeeszadeh,
Volume 13, Issue 3 (12-2021)
Abstract
Introduction: Insulin resistance is a common complication of obesity in communities, so effective and available treatment for this disorder is necessary. The aim of this study was to investigate the effect of Eryngium Billardieri extract on insulin resistance in animal models.
Methods: 30 Wistar rats were prepared from Baqiyatallah University Animal house and randomly divided into control (N = 6) and case (N = 24) groups. After preparing a blood sample,they were fed a normal and high-fat diet for 13 weeks, respectively, and at the end, blood samples were taken again and serum cholesterol, FBS, TG, OGTT and insulin were measured. The case group was then randomly divided into: positive control, E. Billardieri, pioglitazone, and E. Billardieri + pioglitazone groups (N = 6) and treated with (50mg / kg) E. Billardieri and (5mg / kg) pioglitazone by gavage daily for 4 weeks. At the end of treatment, serum samples were prepared again and serum factors were measured by standard laboratory methods.
Results: Treatment with high-fat diet significantly increased the weight of animals (P <0.0001). Cholesterol, sugar, triglyceride and insulin levels also increased significantly but HDL-C decreased (P <0.05). HOMA-IR and TYC indices showed a significant increase (P <0.05). Treatment of animals significantly increased HDL-C and decreased other factors (P <0.01).
Conclusions: The findings of this study indicate a reduction in insulin resistance by E. Billardieri extract, so it can probably be used as a complementary or alternative treatment for insulin resistance

Effect of Aerobic Training with Resveratrol Supplementation on Inflammatory Markers and Insulin Resistance in Women with Type 2 Diabetic Mellitus
Ensiyeh Yazdkhasti, Ameneh Purrahim Ghoroghchi, Mohammad Ebrahim Bahram,
Volume 13, Issue 3 (12-2021)
Abstract
Introduction: The use of supplements and exercise to treat metabolic diseases and disorders has become popular; Therefore, the aim of this study was to evaluate the effect of aerobic exercise and resveratrol supplementation on some inflammatory markers and insulin resistance in women with type 2 diabetes.
Methods: The present study was a quasi-experimental study with a pretest-posttest design. Twenty-four women with type 2 diabetes were voluntarily and randomly divided into three groups: supplement, exercise + supplement (400 mg resveratrol) and control group. Subjects practiced for 6 weeks, 3 sessions per week, and each session lasted 40 to 60 minutes with an intensity of 45-65% of the reserve heart rate. Data analysis was performed using analysis of covariance and paired t-test at the significant level (P <0.005).
Results: The combination of aerobic exercise and resveratrol supplementation significantly reduced c-reactive protein compared to the supplement group. (P=0/02). Also, insulin resistance in the supplement group (P = 0/03) and aerobic exercise + supplement group (P = 0/01) compared to the control group showed a significant decrease.
Conclusions: Based on the findings of the present study, it seems that taking resveratrol supplementation and aerobic exercise can have better results on serum levels of inflammatory agents in women with type 2 diabetes.

Investigating the Effect of Two Types of Aerobic and Resistance Training during a Ketogenic Diet on the Serum Levels of Adipokines and Insulin Resistance in Overweight or Obese Men
Rahim Javan, Kazem Khodaei, Siamak Asri-Rezaei,
Volume 15, Issue 1 (5-2023)
Abstract
Introduction: The purpose of the present study was to investigate the effect of aerobic and resistance training during a Ketogenic Diet (KD) on serum levels of adipokines and insulin resistance indices in overweight or obese men.
Method: A total of 36 overweight or obese men were randomly divided into three groups, namely Aerobic Training during KD (AT-KD), Resistance Training during KD (RT-KD), and KD alone (KD). In addition to following the KD, the training groups performed aerobic or resistance training three days per week for six weeks. For statistical analysis, the mixed two-way analysis of variance test with a significance level of less than 0.05 and SPSS software was used.
Results: The serum levels of adiponectin, resistin, and SFRP5 did not differ significantly between the groups. In all groups, resistin had a significant decrease, whereas adiponectin and SFRP5 had a significant increase, compared to the pre-test. The serum levels of glucose, insulin, and triglycerides, as well as insulin resistance and sensitivity indices, were not significantly different between the groups. A significant decrease in glucose and triglyceride levels was observed in the three groups compared to the pre-test. Both KD and AT-KD groups significantly decreased insulin and HOMA-IR and increased McAuley indices compared to the pre-test. Only the AT-KD group significantly increased the QUICKI index compared to the pretest.
Conclusion: Both AT-KD and RT-KD improved the level of adipokines in overweight or obese men. However, there was no difference between the two types of training. Despite the lack of difference between the two types of exercise, aerobic training may be more effective than resistance training during a KD

Effect of Aerobic Training on Metabolic Factors in Women with Polycystic Ovary syndrome: A Systematic Review and Meta-Analysis
Khadijeh Molaei, Omid Zafarmand, Mehrzad Moghadasi, Mohsen Salesi,
Volume 17, Issue 1 (3-2025)
Abstract
Introduction: Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders, the main factors of which are insulin resistance and obesity. The aim of this study was to investigate the effect of aerobic training on metabolic factors in women with PCOS.
Method: A systematic search of English and Farsi articles published in PubMed, Web of Science, Civilica, Scopus, Sid, and Magiran databases was conducted until April 2024. The present meta-analysis was conducted to investigate the effect of aerobic exercise on metabolic factors in women with PCOS. The mean difference and 95% confidence interval (CI) were calculated using a random effect model. Heterogeneity was evaluated using the (I2) test. Publication bias was evaluated by visual analysis of the funnel plot and Egger's test.

Results: In total, 10 studies with 12 interventions and 460 women with PCOS were meta-analyzed. The results showed that aerobic exercise significantly reduced body mass index, waist-to-hip ratio, and body fat percentage compared to the control group in women with PCOS (P<0.05). However, aerobic exercise did not significantly change glucose, insulin levels, and insulin resistance compared to the control group in women with PCOS (P>0.05).
Conclusion: The results of the present meta-analysis showed that aerobic training improved the metabolic status of patients with PCOS and these beneficial effects were not associated with changes in insulin resistance.

 

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