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Showing 2 results for Melatonin
Protective effect examination of exogenous Progesterone and melatonin after transient ischemia on CA1 region of hippocampus in adult male rat.
P Ebrahimnia , F Abolhasani , M Shiasi , N Marefati , A Hedayatpour ,
Volume 8, Issue 3 (12-2016)
Abstract

Background & Objectives: Stroke is the second leading cause of death worldwide and is one of the main causes of long-term disabilities. The aim of this study was to assess the effect of Melatonin and Progesterone on stroke complications.

Materials and Methods: Sixty four male wistar rats were enrolled in the present study. Common carotid arteries were closed for 20 minutes. Then the animals were treated with 8 mg/kg Progesterone and10 mg/kg Melatonin. Moriss water maze test was done after 2 weeks. Then the animals were sacrificed and histological examination was performed.

Results: The results showed that Progesterone and Melatonin increased the number of pyramidal cells and improved spatial memory in comparison with the ischemic and solvent groups (p<0.05). There wasn’t any significant difference between treatment groups (p>0.05)

Conclusion: It seems that the Progesterone and  Melatonin usage have beneficial effects on improving spatial memory and behavioral functions after stroke.


Evaluation of Different Doses of Melatonin Effect on Post-Operation Pain Score in Patients Who Underwent Caesarian Section with Spinal Anesthesia, a Double Blind Clinical Trial
Shahram Borjian Boroojeny , Setareh Hagghi, Seyede Maryam Hojjat ,
Volume 12, Issue 2 (10-2020)
Abstract
Introduction: Due to the importance of pain control in the postoperative period, prescribing painkillers reduces postoperative complications by improving patients' pain. This study evaluated the effect of different doses of Melatonin on postoperative pain in cesarean section patients under spinal anesthesia.
Methods: In this clinical trial, 150 pregnant women enrolled the study who were candidates for elective cesarean section referring to Imam Ali (AS) Hospital in Zahedan in 1398. Patients were randomly assigned to 3 groups of melatonin 1.5 and 3 mg two hours before spinal and control groups. The severity of the pain and the need for analgesics were assessed in groups. In the end, data analyzed using SPSS software ver. Twenty-three by ANOVA and chi-square statistical tests.
Results: The mean age of the patients was 26.3 ± 4.7 years. The results showed that with increasing melatonin dose, patients' pain decreased during recovery, 6 and 12 hours after that (P < 0.05). The first painkiller administration time was significantly higher in patients receiving Melatonin than the control group (P < 0.05). There was no significant difference in postoperative adverse effect frequencies between groups (P < 0.05).
Conclusions: Melatonin in different doses can be used for pain control and increasing the painlessness duration in the cesarean section

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