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Showing 2 results for Resveratrol

Behnaz Shafie, Jalal Pourahmad, Mohsen Rezaei,
Volume 11, Issue 1 (5-2019)
Abstract

Introduction: Acrolein is an important environmental, food and water pollutant that plays an important role in the development of several diseases. Resveratrol is a phenolic compound with antioxidant properties found in fruits such as grapes, berries and peanuts. The purpose of this study was to evaluate the protective effect of resveratrol in preventing Acrolein-induced toxicity in isolated mitochondria from the rat liver. Methods: Rat liver mitochondria were isolated by differential centrifugation. Different concentrations of Acrolein (100 μM to 2000 μM) were used to obtain an IC50. Different concentrations of resveratrol (2.5 μM to 40 μM) were then applied on mitochondria in the presence of Acrolein toxicity.
Results: Acrolein IC50 was obtained via MTT assay as 400 μM. No toxic effect was observed for resveratrol and in the presence of Acrolein, there was a significant reduction in mitochondrial survival even at high concentrations of resveratrol compared to the control group (P < 0.001).
Conclusions: The results of these study showed that resveratrol failed to exhibit a protective effect against acute Acrolein toxicity and just because a protective substance could be a marvelous antioxidant does not mean that it can prevent the mitochondrial damage resulted from any toxicant.

Ensiyeh Yazdkhasti, Ameneh Purrahim Ghoroghchi, Mohammad Ebrahim Bahram,
Volume 13, Issue 3 (12-2021)
Abstract

Introduction: The use of supplements and exercise to treat metabolic diseases and disorders has become popular; Therefore, the aim of this study was to evaluate the effect of aerobic exercise and resveratrol supplementation on some inflammatory markers and insulin resistance in women with type 2 diabetes.
Methods: The present study was a quasi-experimental study with a pretest-posttest design. Twenty-four women with type 2 diabetes were voluntarily and randomly divided into three groups: supplement, exercise + supplement (400 mg resveratrol) and control group. Subjects practiced for 6 weeks, 3 sessions per week, and each session lasted 40 to 60 minutes with an intensity of 45-65% of the reserve heart rate. Data analysis was performed using analysis of covariance and paired t-test at the significant level (P <0.005).
Results: The combination of aerobic exercise and resveratrol supplementation significantly reduced c-reactive protein compared to the supplement group. (P=0/02). Also, insulin resistance in the supplement group (P = 0/03) and aerobic exercise + supplement group (P = 0/01) compared to the control group showed a significant decrease.
Conclusions: Based on the findings of the present study, it seems that taking resveratrol supplementation and aerobic exercise can have better results on serum levels of inflammatory agents in women with type 2 diabetes.


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