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Showing 7 results for Infertility
Evaluation of prognostic factor in IVF cycle with oocyte donation
Z Heidar , M Mirzamoradi , A Afshari, M Pourhoseingholi ,
Volume 7, Issue 2 (9-2015)
Abstract

Background & objectives: This study was aimed in order to assessment of pregnancy rate and prognostic factor in success rate of oocyte donated IVF cycles in women who candidated for oocyte donated cycle. Methods & Material: This was a prospective study of 100 women who because of different reasons such as premature ovarian failure , genetic problem and decreased ovarian reserve were candidate for IVF cycle with oocyte donation. Prognostic factors including age of donor and recipient, BMI of both, number of oocyte retrieved and embryos, endometrial thickness and emotional state of recipients and pregnancy rate were assessed. Results: in this study pregnancy rate was 59%. Between different parameters BMI of both donor and recipients has statistically significant negative correlation with IVF successes rate. (CI=95% p< 0.05)Younger age of donor and recipient has positive but not statistically significant effect on pregnancy rate. With frequent psychiatric consultation all recipients have a good emotional state and completely accepted the baby as her own child. Conclusion: IVF with donated oocyte is a highly successful treatment in women who are candidate for donation. Lower BMI in addition to health status has positive effect on pregnancy rate. Lower age pregnancy for both donor and recipient accompanied with better prognosis.


Seminal Vesicle Agenesis: A Rare Case Report in Male Infertility
Abdolah Razi, Ramin Haghighi, Farhad Vafaei,
Volume 10, Issue 3 (12-2018)
Abstract
There are few reports on infertility associated with seminal vesicle agenesis. We report a case of seminal vesicle agenesis with low volume of semen and infertility. The laboratory tests, physical examination, and trans-rectal ultrasound were checked. Based on the findings andoutcomes, the patient was referred for biopsy.
An Overview of Probiotics for Prevention and Treatment
Mohammadreza Safdari, Abdollah Razi, Molood Safarirad, Seyed Javad Pournaghi, Shima Shekari, Peiman Alesheikh, Maryam Rameshrad,
Volume 13, Issue 1 (6-2021)
Abstract
Introduction: Probiotics are living microorganisms that have beneficial effects on host health. They are mainly residents of the gastrointestinal tract. This study aimed to introduce the effects of probiotics in diseases such as obesity, diabetes, infertility, gastrointestinal diseases, and the effect on vaccination efficacy.
Methods: Herein, the newest relevant data that evaluated the effects of probiotics in the treatment of the aforementioned diseases were collected from Scopus and PubMed.
Results: The results showed that probiotics have a significant effect on controlling obesity and diabetes by regulating the balance of energy in the body. They modulate the level and type of autoantibodies, beta-cell autoimmunity and appetite-regulating hormones. Furthermore, these organisms reduce the absorption of dietary free fatty acids in the small intestine and increase the resistance of the intestinal barrier. Based on the gathered data, they are effective in improving bowel inflammatory disease, infertility, and depression by increasing the amount of pepsinogen and decreasing mucosal disorders and stress. They have a fantastic role in regulating the immune system, increasing sex hormones, and reducing inflammation. These microorganisms are also effective in improving the vaccination efficacy by regulating the production of antibodies and the cellular immune response.
Conclusions: Based on the results of this study, special species of probiotics could be considered a good candidate in adjuvant therapy of diseases that are related to human immunity dysfunction.

Assessment of the frequency of types and causes of infertility in infertile couples referring to the Bojnurd infertility treatment center during the years 2018 to 2023
Haniye Masoumi , Maryam Hassanzadeh Bashtian, Tooba Farazmand, Arezoo Chahi, Elham Sharifian,
Volume 16, Issue 3 (9-2024)
Abstract
Introduction: Infertility is defined as failure to conceive a pregnancy despite a year or more of regular sexual activity without contraception55. Infertility is divided into primary and secondary, and its etiologies include male, female, male and female causes, as well as unexplained. Therefore, the present study aimed to determine the types and causes of infertility in couples referring to an infertility treatment center in Bojnurd during 2018-2023.
Method: This cross-sectional study was conducted using a checklist made by the researcher on all couples who were referred to the infertility clinic in the Bent-Alhoda Hospital, Bojnurd, in North Khorasan, from 2018 to 2023. The information was extracted from the files or contact with the patients in cases of non-registration. Thereafter, data were entered into the SPSS statistical software (version 25). Following that, analysis was performed using descriptive indicators, frequency distribution, and analytical statistical tests, namely Chi-Square, independent t-test, and one-way analysis of variance, at a confidence level of 95%.
Results: The mean age scores of women and men were 30.04±6.65 and 34.28±7.14 years, respectively. The mean body mass index of women was 26.10±4.87 Kg/m2. Moreover, 87.3% of women were unemployed, and most men were freelancers. The majority of women (76%) had no underlying disease. The most common types and etiology of infertility were related to primary infertility (55.9%) and unexplained causes (38.5%), retrospectively.
Conclusion: Training classes to inform couples about the controllable risk factors of infertility is an essential step towards reducing the incidence of these factors.

Mental health and its relationship with quality of life in pregnant Iranian women with a history of primary infertility
Farideh Golshani, Shirin Hasanpour, Mojgan Mirghafourvand, Soheila Bani,
Volume 16, Issue 3 (9-2024)
Abstract
Introduction: Considering the relatively high prevalence of infertility and its numerous psycho-social problems, the present study was conducted with the aim of investigating stress, depression, and anxiety and their relationship with the quality of life in pregnant women with a history of primary infertility.
Method: This descriptive-analytical cross-sectional study was conducted on 120 pregnant women with a history of primary infertility who referred to the infertility clinic of Al-Zahra Hospital in Tabriz. Eligible participants were selected using a convenient sampling method. Data were collected using an individual-social questionnaire, the Cohen's Perceived Stress Scale, Edinburgh Postnatal Depression Scale, Vandenberg's Pregnancy-Related Anxiety Questionnaire, and Quality of Life Gravidarum. Data analysis was done in SPSS24 software using Pearson and Spearman correlation tests, independent t-test, one-way ANOVA, and multivariate linear regression.
Results: The median (percentile 25-75) of perceived stress score in mothers was 44.0 (40.2-46.0). The mean±standard deviation scores of anxiety, depression, and quality of life were 66.1±11.4 (score range: 17-119), 16.3±3.2 (score range: 0-30), and 32.3±5.2 (score range: 9-63), respectively. There was no significant correlation between perceived stress and depression and quality of life; however, a significant negative correlation was observed between anxiety and quality of life.
Conclusion: The results of the present study indicated a decrease in mental health in pregnant women following primary infertility. Moreover, anxiety scores had a significant and inverse correlation with quality of life. Therefore, it seems necessary to provide programs to improve the mental health of these women along with routine pregnancy care by health care providers.

Investigating the Protective Effects of Royal Jelly on Sperm Parameters in Animal Studies: A Narrative Review
Maryam Mohammadi, Morad Ali Zareipour, Mitra Savabi-Esfahani, Fateme Moshirinia, Maryam Dehghan, Alireza Khani,
Volume 17, Issue 1 (3-2025)
Abstract
Introduction: Natural supplements, such as royal jelly, are commonly used to improve health and well-being in the world and may be a successful treatment for damaged sperm exposed to environmental and chemical pathogens. Therefore, the present study was conducted with the aim of investigating the protective effects of royal jelly on sperm parameters using a narrative review method.
Methodology: The present study was conducted using a systematic review approach. A comprehensive search was conducted in various databases, including ISI, Web of Science, Cochrane, Pubmed, Google Scholar, ProQuest, and Ovid, as well as Persian databases, including ISC, SID, and Magiran, from January 2010 to March 2023. The research was carried out using Persian keywords: “Male infertility,” “Sperm parameters,” “Royal jelly,” “Protective effect,” “Fertility promotion,” and “Clinical trial” and their equivalent English keywords. The search results were 58 articles, of which 11 articles were reviewed according to the objectives of the study.
Findings: Royal jelly consumption is effective on sperm parameters and can improve sperm viability, number, and motility. It also has a protective effect on the negative effects of heat stress, nicotine consumption, exposure to lead compounds, and the use of drugs, such as bleomycin and hydroxyurea.
Conclusion: Royal jelly, as a protective agent, improves sperm viability, number, and motility and is effective at medium and high doses. However, very high or low doses have little effect, and further studies are needed to determine the optimal dose. Human clinical research is needed to determine the effects and appropriate dosage of royal jelly on male fertility with sperm disorders.

The Use of Stem Cell Therapy for the Treatment of Infertility: Approaches within an Ethical Framework
Parisa Feyzi, Aghil Farzaneh, Seyed Morteza Mousavi Jajarmi, Fatemeh Oroojalian,
Volume 17, Issue 2 (6-2025)
Abstract
Physical and mental health, as well as hormonal imbalances, are related to issues concerning infertility and fertility disorders. Infertility rates have increased globally due to various reasons. Recognizing the psychosocial impact of infertility and its effects on individuals, there has been a growing emphasis on its treatment in recent years. Assisted reproductive technology can only address approximately 50% of cases, often posing significant risks and failing to resolve the main cause of infertility. Pluripotent stem cells, capable of differentiating into nearly any cell type, are a promising option for stem cell-based fertility treatments that could potentially address genetic diseases in children. These advancements in reproductive biotechnology present both challenges and opportunities for managing infertility issues stemming from various unknown factors. Building on this foundational research, the concept involves using surplus blastocysts from couples for research with therapeutic purposes in medical studies and experiments. However, the ethical considerations concerning the use of stem cells are crucial in the context of human ethics and medical research. Ethical considerations include authorized sources for stem cell production, the use of surplus embryos, obtaining free and informed consent from parents, providing accurate information, maintaining confidentiality, and avoiding unnecessary collection of personal information. While the use of stem cells in infertility treatment should not be prohibited, ethical principles must guide their application. This review article discusses the ethical implications of using stem cells in infertility treatments

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