Abstract Background & Objectives: Brucellosis is a Zoonotic infection, occurs in different parts of the world especially in developing countries and is important both public health and economically aspects. The aim of this study was to determine epidemiological aspects of disease in Northern Khorasan province, north east of Iran. Material & Methods: Several data sources in this cross-sectional study were used such as all documents in province and districts health center and also documents in private laboratories in the province. Demographical and laboratory information of all cases that diagnosed during 2006–2011 were checked. We used SPSS16 software to do statistical analysis of the samples and presented with descriptive analysis, chi-square and T-test) P > 0.05). Results: We retrospectively evaluated 1310 patients with brucellosis in North Khorasan province during the study. The prevalence rate of the disease was 26.6 per 100,000 annually. 55.3% of patients were male. More cases have seen in Bojnurd district (26.4%). The majority of the patients were from rural (71.5%). The monthly variation of disease shows that most of cases diagnosed in springs and June. There was a significant correlation between gender and place of residence. Conclusion:The results obtained from this work indicate that the prevalence rate of brucellosis in North Khorasan province is higher than average rate of Iran country. Such a high prevalence rate is alarming and requires control and prevention measures.
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