Volume 14, Issue 4 (3-2023)
2023, 14(4): 75-86 |
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Ethics code: IR.HSU.REC.1399.020
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Shamshadi B, Askari R, Rezaei R, Haghighi A H. Investigation of an Increase in the Expression of the Mir146a Gene in The Hippocampus and a Decrease in the Levels of Blood Sugar, Insulin, and Insulin Resistance in Elderly Diabetic Rats after a Period of High-Intensity Interval Training. North Khorasan University of Medical Sciences 2023; 14 (4) :75-86
URL: http://journal.nkums.ac.ir/article-1-2699-en.html
URL: http://journal.nkums.ac.ir/article-1-2699-en.html
1- Ph.D. Student of Sports Physiology, Department of Sports Physiology, Faculty of Sports Sciences, Hakim Sabzevari University, Sabzevar, Iran
2- Associate Professor of Sports Physiology, Department of Sports Physiology, Faculty of Sports Sciences, Hakim Sabzevari University, Sabzevar, Iran ,r.askari@hsu.ac.ir
3- Assistant Professor of Sports Physiology, Department of Sports Sciences, Faculty of Educational Sciences and Psychology, Shiraz University, Shiraz, Iran
4- Professor of Sports Physiology, Department of Sports Physiology, Faculty of Sports Sciences, Hakim Sabzevari University, Sabzevar, Iran
2- Associate Professor of Sports Physiology, Department of Sports Physiology, Faculty of Sports Sciences, Hakim Sabzevari University, Sabzevar, Iran ,
3- Assistant Professor of Sports Physiology, Department of Sports Sciences, Faculty of Educational Sciences and Psychology, Shiraz University, Shiraz, Iran
4- Professor of Sports Physiology, Department of Sports Physiology, Faculty of Sports Sciences, Hakim Sabzevari University, Sabzevar, Iran
Abstract: (1075 Views)
Introduction: MicroRNAs have been reported as potentially valuable biomarkers for various diseases, including diabetes, heart diseases, neurological diseases, and age-related diseases. The present study aimed to investigate the effect of 8 weeks of intense intermittent exercise on the expression of mir146a, blood sugar, insulin, and insulin resistance in the hippocampus of aged diabetic male rats.
Method: This study was performed on 40 male Wistar rats aged 18-21 months with an average weight of 280±20 g. After becoming diabetic through streptozotocin solution, they were randomly divided into 4 groups, including 1) healthy high-intensity interval training (HIIT) exercise, 2) healthy control, 3) diabetic HIIT exercise, and 4) diabetic control. It should be mentioned that each group included 10 rats. The exercise groups exercised 5 days a week according to the HIIT programs for 8 weeks. The collected data were analyzed using GraphPad Prism software (version 8) at a significance level of P<0.05.
Results: The results showed that 8 weeks of HIIT exercise increased the expression of mir146a in both of the exercise groups, compared to the diabetic control group (P<0.001). Moreover, the blood sugar, insulin, and insulin resistance levels significantly decreased in the diabetic exercise, healthy HIIT exercise, and healthy control groups, compared to the diabetic control group (P<0.001).
Conclusion: It can be concluded that 8 weeks of HIIT training, which increased the expression of mir146a, can reduce neuronal destruction in the hippocampus region. Moreover, it can be used as a suitable non-therapeutic mechanism for diabetics to prevent or reduce damage in this brain region that is related to cognitive abilities.
Method: This study was performed on 40 male Wistar rats aged 18-21 months with an average weight of 280±20 g. After becoming diabetic through streptozotocin solution, they were randomly divided into 4 groups, including 1) healthy high-intensity interval training (HIIT) exercise, 2) healthy control, 3) diabetic HIIT exercise, and 4) diabetic control. It should be mentioned that each group included 10 rats. The exercise groups exercised 5 days a week according to the HIIT programs for 8 weeks. The collected data were analyzed using GraphPad Prism software (version 8) at a significance level of P<0.05.
Results: The results showed that 8 weeks of HIIT exercise increased the expression of mir146a in both of the exercise groups, compared to the diabetic control group (P<0.001). Moreover, the blood sugar, insulin, and insulin resistance levels significantly decreased in the diabetic exercise, healthy HIIT exercise, and healthy control groups, compared to the diabetic control group (P<0.001).
Conclusion: It can be concluded that 8 weeks of HIIT training, which increased the expression of mir146a, can reduce neuronal destruction in the hippocampus region. Moreover, it can be used as a suitable non-therapeutic mechanism for diabetics to prevent or reduce damage in this brain region that is related to cognitive abilities.
Type of Study: Orginal Research |
Subject:
Basic Sciences
Received: 2022/08/29 | Accepted: 2022/11/8 | Published: 2023/02/26
Received: 2022/08/29 | Accepted: 2022/11/8 | Published: 2023/02/26
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