Volume 17, Issue 2 (Summer 2025)
2025, 17(2): 7-0 |
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Ethics code: IR.NKUMS.REC.1402.108
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Alidadiani A, Alesheikh P, Zarghami Moghaddam P, Saadati H, Babaii Vastani A. In Vitro Comparison of the Combined Effects of Different Concentrations of Extracts of the Nettle (Urtica Diocia) and Sage (Salvina Officinalis) with Chlorhexidine Mouthwash on the Oral Pathogen from Dental Plaque (Streptococcus Mutans). North Khorasan University of Medical Sciences 2025; 17 (2) :7-0
URL: http://journal.nkums.ac.ir/article-1-3220-en.html
URL: http://journal.nkums.ac.ir/article-1-3220-en.html
Aynaz Alidadiani *1 
, Peyman Alesheikh2 , Parstoo Zarghami Moghaddam3 , Hassan Saadati4 , Alireza Babaii Vastani5
, Peyman Alesheikh2 , Parstoo Zarghami Moghaddam3 , Hassan Saadati4 , Alireza Babaii Vastani5
1- Esthetic and Restorative Specialist, Assistant Professor, Faculty of Dentistry, North Khorasan University of Medical Sciences, Bojnurd, Iran , i_alidad@yahoo.com
2- PhD in Chinese Medicine, Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran
3- PhD in Microbiology, Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran
4- Assistant Professor, Department of Epidemiology and Biostatistics, School of Health, North Khorasan University of Medical Sciences, Bojnurd, Iran
5- Doctor of General Dentistry, Faculty of Dentistry, North Khorasan University of Medical Sciences, Bojnurd, Iran
2- PhD in Chinese Medicine, Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran
3- PhD in Microbiology, Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran
4- Assistant Professor, Department of Epidemiology and Biostatistics, School of Health, North Khorasan University of Medical Sciences, Bojnurd, Iran
5- Doctor of General Dentistry, Faculty of Dentistry, North Khorasan University of Medical Sciences, Bojnurd, Iran
Abstract: (11 Views)
Introduction: Dental caries is an infectious disease caused by bacterial colonization. Streptococcus mutans, which is the main cause of human dental caries, is mainly found in biofilms that form on tooth surfaces, also known as dental plaque. Chlorhexidine is the most commonly used standard mouthwash; however, due to its side effects, researchers are looking for alternatives. This study aimed to evaluate the combined effect of different concentrations of extracts of the Nettle (Urtica Diocia) and Sage (Salvina Officinalis) with chlorhexidine mouthwash on the oral pathogen from dental plaque (Streptococcus Mutans).
Method: A mixture was prepared from different concentrations of ethanolic extracts of the Nettle (Urtica dioica) and Sage (Salvina officinalis). Following that its effect at different dilutions against Streptococcus mutans bacteria was investigated using disk diffusion, well plate, and biofilm inhibition methods.
Results: In all methods (disk diffusion, well plate, and biofilm formation), the highest effectiveness observed after chlorhexidine and ciprofloxacin was related to Sage (Salvina Officinalis) extract (100%). According to the results of biofilm formation, only Sage (Salvina Officinalis) extract (100%) showed appropriate effectiveness against Streptococcus Mutans bacteria.
Conclusion: The results of the present study showed that the effectiveness of chlorhexidine and ciprofloxacin is greater than that of herbal extracts; however, among the extracts tested, the highest effectiveness is related to Sage (Salvina Officinalis) (100%).
Method: A mixture was prepared from different concentrations of ethanolic extracts of the Nettle (Urtica dioica) and Sage (Salvina officinalis). Following that its effect at different dilutions against Streptococcus mutans bacteria was investigated using disk diffusion, well plate, and biofilm inhibition methods.
Results: In all methods (disk diffusion, well plate, and biofilm formation), the highest effectiveness observed after chlorhexidine and ciprofloxacin was related to Sage (Salvina Officinalis) extract (100%). According to the results of biofilm formation, only Sage (Salvina Officinalis) extract (100%) showed appropriate effectiveness against Streptococcus Mutans bacteria.
Conclusion: The results of the present study showed that the effectiveness of chlorhexidine and ciprofloxacin is greater than that of herbal extracts; however, among the extracts tested, the highest effectiveness is related to Sage (Salvina Officinalis) (100%).
Type of Study: Orginal Research |
Subject:
Basic Sciences
Received: 2024/09/7 | Accepted: 2024/12/30 | Published: 2025/05/29
Received: 2024/09/7 | Accepted: 2024/12/30 | Published: 2025/05/29
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