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Showing 8 results for Diabetes Mellitus
Effects of a 30-day oral regime of glibenclamide and walnut leaf aqueous extract on serum insulin and HbA1c levels in normal and alloxan-induced diabetic rats
M Noureddini , F Rezaei Josheghan ,
Volume 5, Issue 2 (9-2013)
Abstract

Abstract Background & Objective: walnut has been widely used for the treatment of diabetes mellitus in traditional medicine. Nowadays more research is carrying out to find out the mechanisms of walnut effect on blood glucose. This study was conducted to compare the effects of oral administration of glibenclamide and the aqueous extract of walnut leaf on the serum levels of insulin and HbA1c in normal and diabetic rats. Materials and Methods: In present study, 120 adult male rats (Sprague Dawley ) were divided into twelve groups as follow: control, control treated with glibenclamide(4mg/kg),normal treated with extracts extract(50,10,50 mg/kg) alloxan-induced diabetic rats(170mg/kg/ ,ip) ,diabetic treated with glibenclimide(4mg/kg), diabetic treated with extract[10,50,150,300,500 mg/kg]-,each groups received daily gavages for one month. Insulin and HbA1c levels were determined one day after the completion of experiments. Results: Results showed a significant decrease in HbA1c and increase in insulin level of diabetic rats received walnut leaf aqueous extract compared to the control diabetics in a dose-dependent manner (p<0.05). No significant effect was seen in normal groups. In both groups the effects were the same as glibenclamide. Conclusion: One proposed mechanism for the effects of queous extract of walnut leaf may be through the increment in the insulin level either in secretion or the decrement in its degradation.


Psychometric properties of the healthful eating belief scales for type 2 diabetics
H Rohani , Aa Eslami , M Raei , H Tavakoli Ghouchani , A Afshari ,
Volume 6, Issue 2 (9-2014)
Abstract

Abstract Background & Objectives: Moderate changes in diet have been shown to prevent or delay complications of type 2 diabetes. Understanding beliefs about healthful eating among persons at risk for diabetes may help to develop interventions to change these beliefs as a mechanism for changing dietary behaviors in this population. Therefore objective of this study is to examine the validity and reliability of Theory of Planned Behavior (TPB) scales for healthful eating for persons with diabetes. Material & Methods: Cross-sectional study was conducted in Semirom diabetes clinic, using a self-administered questionnaire. Participants were 142 adults who had not complications of diabetes. Variables measured were attitude, subjective norm, perceived behavioral control, and intention to eat a healthful diet. Construct validity was assessed with factor analyses. Reliability of the scales was assessed with Cronbach alpha and a 2-month test-retest. Results: Factor analysis loadings were greater than 0.4. Cronbach alphas for attitude, subjective norm, perceived behavioral control, and intention were .92, .91, .91 and .90, respectively. Factor analysis revealed that the constructs fit well for predicting intention to eat a healthful diet. Test-retest revealed 2-month stability of the scales. Conclusions: Questionnaire for measuring TPB constructs attitude, subjective norm, perceived behavioral control were valid and reliable for use with adults with diabetes.


Comparison of the effect of non-surgical periodontal therapy with and without systemic Doxycycline on glycemic status and clinical periodontal parameters in type II diabetic patients with chronic periodontitis
A Mozaffari , M Rezvan Behbahani , B Asgartooran ,
Volume 8, Issue 3 (12-2016)
Abstract

Background and objective: The effect of non-surgical periodontal treatment on periodontal condition and metabolic control is a controversial issue. Therefore, the present study was designed to compare the effects of non-surgical periodontal therapy with and without systemic doxycycline on glycemic status and clinical periodontal parameters in type II diabetic patients.

Methods and materials: In this double blind randomized controlled clinical trial, fifty diabetic patients were enrolled. The periodontal therapy involved scaling with ultrasonic curettes. The patients received 100 mg Doxycycline twice on the first day and once per day after that for two weeks in case group and placebo in control group. Plaque Index (PI), Clinical Attachment Level (CAL) and Probing Depth (PD) were recorded on baseline and 1, 2 and 3 months after treatment. FBS(Fasting Blood Sugar) and HbA1C were also recorded at baseline and 3 months after the treatment and analyzed by t and Paired t-Test.

Result: Periodontal parameters such as PD (P<0.04),CAL(P<0.05), and HbA1C (P=0.03)were reduced significantly in Doxycycline group, but FBS had not significant differences between two groups (P=0.7)

Conclusion: Although both periodontal treatment regimens are effective in type II diabetics, the use of Doxycycline as an adjunct provided more significant improvement in periodontal and glycemic control


The Effect of Combined Aerobic- Resistance Exercise Training on Serum Concentrations of CTRP3 and Interleukin-6 in Men with Type 2 Diabetes
Mehdi Zarei, Javad Nakhzari Khodakheir,
Volume 12, Issue 4 (2-2021)
Abstract
Introduction: Studies have shown that CTRP3, as an insulin-independent anti-inflammatory adipokine, affects metabolism and regulates glucose metabolism. The aim of this study was to investigate the effect of combined aerobic- resistance training on serum concentrations of CTRP3 and interleukin-6 in men with type 2 diabetes.
Methods: In this quasi-experimental study, 24 male patients with type 2 diabetes were randomly divided into two groups of combined resistance aerobic exercise (n = 12) and control (n = 12). The subjects of the training group performed combined aerobic- resistance exercises 3 sessions per week for 12 weeks. Before and after 12 weeks of exercise program, blood samples were taken to measure the concentration of CTRP3 and interleukin-6 and anthropometric measurements of the subjects. Analysis of covariance was used to analyze the data.
Results: After 12 weeks in the exercise group, fasting glucose (P = 0.014), HbA1c (P = 0.001), body weight (P = 0.048), body mass index (P = 0.037), body fat percentage (P = 0.001), fat mass (P = 0.001) were significantly decreased compared to the control group, but there was a significant difference in insulin (P = 0.054), lean mass (P = 0.987) and WHR (P = 0.291) between the two groups. After 12 weeks, the concentration of CTRP3 (P = 0.040) in the training group increased and IL-6 (P = 0.028) concentration decreased significantly compared to the control group.
Conclusions: 12 weeks of combined aerobic- resistance training in men with type 2 diabetes in addition to glycemic control leads to a significant increase in CTRP3 and a significant decrease in interleukin-6.

Effect of Aerobic Training with Resveratrol Supplementation on Inflammatory Markers and Insulin Resistance in Women with Type 2 Diabetic Mellitus
Ensiyeh Yazdkhasti, Ameneh Purrahim Ghoroghchi, Mohammad Ebrahim Bahram,
Volume 13, Issue 3 (12-2021)
Abstract
Introduction: The use of supplements and exercise to treat metabolic diseases and disorders has become popular; Therefore, the aim of this study was to evaluate the effect of aerobic exercise and resveratrol supplementation on some inflammatory markers and insulin resistance in women with type 2 diabetes.
Methods: The present study was a quasi-experimental study with a pretest-posttest design. Twenty-four women with type 2 diabetes were voluntarily and randomly divided into three groups: supplement, exercise + supplement (400 mg resveratrol) and control group. Subjects practiced for 6 weeks, 3 sessions per week, and each session lasted 40 to 60 minutes with an intensity of 45-65% of the reserve heart rate. Data analysis was performed using analysis of covariance and paired t-test at the significant level (P <0.005).
Results: The combination of aerobic exercise and resveratrol supplementation significantly reduced c-reactive protein compared to the supplement group. (P=0/02). Also, insulin resistance in the supplement group (P = 0/03) and aerobic exercise + supplement group (P = 0/01) compared to the control group showed a significant decrease.
Conclusions: Based on the findings of the present study, it seems that taking resveratrol supplementation and aerobic exercise can have better results on serum levels of inflammatory agents in women with type 2 diabetes.

Effectiveness of Team Member Teaching Design on diabetes-related knowledge of practice nurses and the community covered by them
Mohamad Reza Mansoorian, Shahla Khosravan, Moosa Sajjadi, Mansoor Soltani, Akram Khazaei,
Volume 14, Issue 4 (3-2023)
Abstract
Introduction: The use of modern teaching methods to train practice nurses empowers them to play their roles. This study aimed to compare the effectiveness of Team Member Teaching Design (TMTD) and the routine teaching methods on the diabetes-related knowledge of the community covered by practice nurses.
Method: This quasi-experimental study was conducted on 24 practice nurses and 192 persons from the community covered by them. The samples were assigned into two groups of experiment and control via a simple randomization method. Diabetes care education was presented to the intervention and control groups using the TMTD and routine methods, respectively. The required data were collected through a researcher-made questionnaire related to diabetes and the TMTD model. The gathered data were analyzed in the SPSS-20 statistical package using the independent t-test, paired t-test, and repeated measures analysis of variance.
Results: There was a significant difference between the mean scores of knowledge on TMTD between the practice nurses in the control and intervention groups after the intervention (P<0.001). The mean knowledge scores improved in the intervention group (12.08±1.44) compared to the controls (0.577±0.166) over time. Similarly, there were significant differences regarding the mean scores of diabetes-related knowledge in the community covered by the practice nurses in the experimental and control groups after the intervention (13.23±1.30 vs. 10.37±1.89) and at follow-up (12.42±1.49 vs. 9.96±1.72, respectively) (P<0.001).
Conclusion: The TMTD increased the learning of practice nurses and the community covered by them more than the routine teaching method.

The effect of curcumin and nanocurcumin in improving periodontal lesions in patients with diabetes: (A systematic review)
Amirhossein Majbouri Yazdi, Marzyeh Mahmoudimanesh, Shima Abdolahi, Mehdi Hares Abadi, Maryam Yazdani, Azar Shokri, Yasaman Aleyasin, Faria Jafarzadeh,
Volume 16, Issue 1 (3-2024)
Abstract
Introduction: Inflammatory gum disease is a complication of diabetes that can impact blood sugar control. Current treatments for diabetic patients, such as scaling and gum surgery, are invasive. The present study aimed to review the effectiveness of curcumin in improving periodontal lesions in diabetic patients.
Method: Four databases of Scopus, PubMed, Web of Science, and Google Scholar were searched for relevant studies without any time or language limitations. MeSH keywords and text words related to "curcumin," "periodontal lesions," and "diabetes" were used to search in the title-abstract field. The titles, abstracts, and full text of the studies were reviewed to identify eligible studies. The present study followed PRISMA guidelines for implementation and reporting.
Results: Finally, 10 studies were included in the review. The results showed that curcumin can reduce free radicals and inflammatory factors, improving inflammation. Gums in diabetic patients should be scaled alone or with invasive methods.
Conclusion: It seems curcumin may effectively reduce gum inflammation and bone loss in diabetic patients. However, to reach a reliable conclusion, further human studies are required in this field.

Effect of Eight Weeks of Combined Exercises and Consumption of Mulberry Leaf Extract on the Levels of Liver Enzymes in Elderly Males with Type 2 Diabetes
Ali Alikhani, Seyed Hamed Ghiyami, Mohammad Ebrahim Bahram,
Volume 16, Issue 4 (1-2025)
Abstract
Introduction: Type 2 diabetes causes structural and functional changes in the liver to increase the serum levels of liver enzymes. In this regard, the present study aimed to investigate the effect of eight weeks of combined exercises and the consumption of black mulberry leaf extract on the levels of liver enzymes in elderly males with type 2 diabetes.
Method: In this semi-experimental study, 40 elderly males with type 2 diabetes were selected and randomly divided into five groups of 8 cases, namely control, placebo, black mulberry leaf extract, exercise, and black mulberry leaf extract+exercise. The exercises were performed for eight weeks, with three 90-minute sessions per week. Furthermore, 3,000 mg of mulberry leaf extract per day was prescribed along with three main meals. The data were analyzed in SPSS software (version 27) using the two-way ANOVA test at a significance level of 0.05.
Results: Interactive effect of exercise and extract on the values of AST (P=0.001, effect size 0.420), ALP (P=0.001, effect size 0.525), ALT (P=0.001, effect size 0.511), and glucose (P=0.001, effect size 0.460) was significant. Furthermore, a significant decrease was observed in ALT, AST, ALP, and blood glucose levels of the exercise, extract, and exercise+extract groups (P<0.05). The extract+exercise group underwent a greater decrease in the values ​​of AST (20%), ALP (12.90%), ALT (22.30%), and glucose (12%), compared to the pre-test stage.
Conclusion: Implementation of eight weeks of combined exercises and consumption of black mulberry leaf extract seems to improve liver enzymes in elderly males with type 2 diabetes.

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