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Showing 3 results for Spinal Cord
The Effect of Reperfusion after Short Time Ischemic on Spinal Cord on Rat
Gholamhossein Farjah, Masoumeh Mohammadpour,
Volume 10, Issue 4 (3-2019)
Abstract
Introduction: Ischemia plays an important role in the development of pathologic in various neuropathies, and reperfusion improves the pathological and physiological abnormalities of ischemic nerves. In this study, the effect of shortreperfusion time after short time ischemic on spinal cord of rat was investigated.
Methods: Eighteen rats (Sprague-Dawley, 250-350 g), were divided into 3 groups: group I (surgical sham), group II (60 minutes of ischemic abdominal aorta, followed by 48 hours reperfusion), group III (60 minutes of ischemia of the abdominal aorta, followed by 72 hours of reperfusion). All animals were evaluated by (Motor Deficit Index or MDI), Malondialdehide (MDA), Total antioxidant capacity (TAC), and histopathological parameters within 48 hours or 72 hours after surgery.
Results: The mean of MDI scores in groups II and III was not statistically significant (P > 0.05). The mean number of normal motor neueons of spinal cord in group III was significantly lower than group II (P < 0.05). The mean of MDAplasma level in group III was higher than group II, and this difference was significant (P < 0.05). The mean TAC plasma level in group III was significantly lower than group II (P < 0.05).
Conclusions: These results indicate that increasing the time of reperfusion from 48 to 72 hours may increase paralysis in the hind limb of the rat

Effect of Two Types of Aerobic Exercise Programs on NT4 Gene Expression and Motor Performance in Spinally Injured Rats
Mahdi Ziaee Bashirzad, Sadegh Cheragh-Birjandi, Mohamad Amin Younessi Heravi, Reza Salarinia,
Volume 15, Issue 3 (10-2023)
Abstract
Introduction: The present research aimed to investigate the effect of four weeks of selective training on motor performance and neurotrophin4 (NT4) gene expression in the hippocampus of rats with spinal cord injury (SCI).
Method: This experimental study was conducted on adult and young male Wistar rats. The animals were randomly divided into six groups (control group, healthy group with the first exercise protocol, healthy group with the second exercise protocol, SCI group, SCI group with the first exercise protocol, and SCI group with the second exercise protocol; 7 animals in each group). Firstly, animals were subjected to general anesthesia and SCI. After two weeks of recovery, two types of aerobic exercise programs were performed for four weeks. After performing the exercises, Basso Beattie Bresnahan (BBB) test and molecular tests were used to measure the expression of the NT4 gene from the hippocampus of the animals using the qRT-PCR method.
Results: The BBB score in the exercise group compared to the injury group increased significantly. The expression of NT4 in the SCI group was significantly decreased compared to the control group. While, NT4 expression was increased in the SCI + exercise 1 group and in the SCI + exercise 2 group compared to the SCI group, this increased expression was not significantly different between the two groups of SCI + exercise.
Conclusion: The exercise protocols of this study are effective on NT4 gene expression, as well as improving movement in animals with SCI, and could be a factor for axonal growth and neuronal survival in spinal cord injury recovery.

Investigating the Relationship between Resilience and the Care Burden in Caregivers of People with Spinal Cord Injuries Referred to the Iranian Spinal Cord Injury Support Association in 2021
Yasaman Shahmoradi, Mahnaz Seyedoshohadaee, Hamid Haghani,
Volume 17, Issue 1 (3-2025)
Abstract
Introduction: Caring burden is a situation that the caregiver faces during the care of a person with a spinal cord injury. Considering the significant level of stress and care burden created for caregivers in providing care, the concept of resilience becomes important. Considering to importance of the issue, this study was conducted with the aim of determining the relationship between resilience and the care burden of caregivers of people with spinal cord injuries referring to the Iranian Spinal Cord Injury Support Association in 2021.
Method: This research was a cross-sectional descriptive-correlation study. The samples were 196 caregivers of people with spinal cord injuries who referred to the Iranian Spinal Cord Injury Support Association in 2021 and were selected through a continuous sampling method and based on the inclusion criteria. In this study, the demographic form of caregivers and two questionnaires, Connor-Davidson Resilience Scale and Zarit Caregiver Burden, were used. The data were analyzed in SPSS version 26 software using descriptive statistics, statistical tests of Spearman's correlation analysis, independent t-test, and analysis of variance with a significance level of P = 0.001.
Results: The average score of resilience and care burden in caregivers of patients was 63.81±17.32 and 31.07±17.85, respectively. There was a significant negative correlation between resilience and care burden (r=-0.434), so ​​increasing care burden decreased resilience (P<0.001). The results of a one-way analysis of variance showed that there was no statistically significant difference between the location of the lesion and the resilience score (P=0.175) and the caregiving burden score (P=0.540).
Conclusion: The results of this research showed that with a decrease in the resilience of caregivers in people with spinal cord injuries, the burden of caring for them increased. Therefore, reducing the care burden and not caring for the person alone in these people can improve the caregivers' resilience against the surrounding problems and stresses.

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