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Showing 2 results for Cerebellum

R Golmohammadi , M Behashti ,
Volume 6, Issue 2 (9-2014)
Abstract

Abstract Background and Objective: There is no report on the effect of exercise on purkinje cells in cerebellum of by pentyleneterazole (PTZ) induced epileptic rats. Purpose of this study was to determine the effect of physical exercise on cerebellum purkinje cells in epileptic rats. Materials and Methods Forty adult male rats were randomly divided into four equal groups) n=10)including: (1-PTZ+ without exercise, 2- Control+ without exercise, 3- PTZ + exercise, 4- Control + exercise groups). Kindling was done by PTZ ( 40 mg/kg). After 6 week rats were anesthetized and cerebellum dissected out and fixed in formalin. After tissue processing and sectioning, the sections were stained by routine and especial method. Data were analyzed using ANOVA test. Results: The results showed significantly increased the mean number of purkinje cells in cerebellum of the group PTZ+ exercise compared to the PTZ without exercise group. Furthermore, the mean normal cells of purkinje in cerebellum were significantly increased in control + exercise group compared to the control group. The obtained results showed increase Program cell death of of purkinje in the PTZ group of cerebellum compared to the other groups. Conclusion: Decreased number of normal purkinje cells in cerebellum of epileptic rats would be probably related with increase in rate of purkinje cells apoptosis , whereas exercises has positive effect on delaying the apoptosis of purkinje cells.


Behrooz Yahyaei, Leila Khojasteh, Yasaman Janbazi Alamdari,
Volume 15, Issue 1 (5-2023)
Abstract

Introduction: Ketamine is a popular drug for use in various populations, including pregnant women. Of note, the high prevalence of ketamine use may cause disorders, especially in the nervous system. This study aimed to investigate the effect of repeated short-term and long-term anesthesia with ketamine on balance behavior and cerebellar tissue changes in neonatal rats.
Method: In total, 15 female and 3 male rats were prepared and then randomly divided into 3 groups of 5 including control, long-term, as well as short-term and repeated anesthesia with ketamine. Pregnant female rats in the group of long-term anesthesia with ketamine were anesthetized once a week (at a dose of 75 mg/kg), and those in the groups of short-term and repeated anesthesia with ketamine were anesthetized 3 times a week (at a dose of 25 mg/kg). Ketamine injections were given weekly and regularly until the end of pregnancy. In order to evaluate the balance behavior of rats, a balance behavior test was conducted after lactation of all neonates of different groups. Moreover, tissue sampling was performed at the end of the whole period.
Results: Most tissue changes were related to the Purkinje layer in the long-term group. In terms of balance, there were significant differences among different groups in terms of traveling distances and the number of slips.
Conclusion: Increasing the dose of ketamine has mild effects on cerebellar tissue alongside significant effects on balance behavior.


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