Journal of North Khorasan

Background & Objectives:The gallbladder and bileduct epithelium lining of bacteria that are able to create a powerful source for gallbladder disease. Since Helicobacterpylori infection plays an important role in the development of chronic inflammation of the gastric mucosa and provides conditions for the development of gastric adenocarcinoma and peptic ulcer disease, recent reviews showed probability relationship between this bacterium and gallbladder cancer. To determine the frequency of H.pylori in gallbladder samples of patients with cholecystitis and determine pathologic changes.

Material & Methods:100 patients with cholecystitis were investigated randomized.In the operating room aftercholecystectomy, urease test was performed on gallbladder samples; thensamples in formalinsolution transferred to a Afzalipoor hospital laboratory and the sampleswere assessed for H.pylori by Giemsa staining. The pathological changes such as hyperplasia, metaplasia/dysplasia and lymphocytic infilteration were reported by the Department of Pathology.

Results: 23% of samples was positive for H. pylori that 39.1% wasmale and 66.9% was female and 95.7% was chronic cholecystitis and 4.3% was acute. In positive H-pylori cases there was 21.7% cases with pathological change that lymphocytic infilteration and mononuclear cells were seen commonly.

Conclusion: In this study, the prevalence of H. pylori and urease test results were significantly associated with pathologic changesbut had no correlation with age, sex and status.