Journal of North Khorasan

Background & Objectives: Diabetes is associated with impaired glucose and lipid metabolism. Adiponectin is a specific secretory protein from adipose tissue and having an impact on some factors predisposing to diabetes. Considering the antioxidant and antidiabetic properties of curcumin, the aim of this study was to determine the effect of curcumin on serum level of adiponectin and lipid profile in diabetic rats.

Materials & Methods: In this experimental study 32 male rats were divided into four equal groups including; Control, diabetic and experimental diabetic treated with curcumin (100 and 200 mg/kg, ip). The diabetes in diabetic and experimental diabetic groups was induced using an intraperitoneal injection of alloxan. Curcumin was intraperitoneally injected into experimental groups for 25 days. Saline solution was injected to the animals of control and diabetic groups. At the end of injection, the serum level of adiponectin, LDL, HDL, triglyceride, total cholesterol, and glucose were measured. Data was analyzed by ANOVA and Post hoc Tukey statistical tests (p<0.05).

Results: In comparison with diabetic group, LDL, triglycerides, total cholesterol and glucose in experimental diabetic groups treated with 100 and 200 mg/kg of curcumin dose-dependent manner decreased, also adiponectin and HDL significantly increased (p<0.05).

Conclusion: Dose dependent administration of curcumin by increasing adiponectin level, plays a role in regulation of lipid metabolism.