Journal of North Khorasan

Abstract Background & Objectives: Nowadays diabetes is considered a risk factor of nephrolithiasis and the prevalence of uric acid stones has been reported to be higher in diabetic patients. Disorders in kidney aminogenes in diabetic patients result in reduction of urine pH that facilitates the formation of urinary tract stones. Methods & Materials: This study was performed on 210 Patients aged 30-70 with urinary tract stones referring to outpatient clinics of Ghaem hospital and medical center. These patients were evaluated for having overt diabetes. Laboratory tests was performed before hospitalization for surgery.. The removed stones had biochemical analysis. Results: From 210 patients under study, 73 females and 137 males had a mean age of 11.1 ± 44.9. Patients with fasting glucose levels over 126 mg/dL were considered to have diabetes. 28 patients were identified as being diabetic (13.3%). Stones were composed of calcium (66.7%), uric acid (26.7%), and struvite (6.7%). prevalence of females with diabetes was more than males. However, the age and anthropometric and serum biochemistry profile in both groups were similar. The mean serum acid uric level and 24-hour urine uric acid test was higher in diabetic patients. The prevalence of acid uric stones was significantly higher in diabetic patients. Conclusion: Diabetes is a risk factor for urinary tract stones,especially uric acid stones.