Journal of North Khorasan

Abstract Background & Objectives: Letrozole has fewer side effects than clomiphene citrate this drug may be a replacement for clomiphene citrate in induction of ovulation. The aim of this study was to investigate the efficacy of letrozole in ovarian stimulation in infertile women with ovulatory disorders infertility. Materials and Methods: Infertile women with ovulatory disorders hospitalized in Imam Khomeini Hospital in Sary were randomly and double-blind assigned in a 1:1 ratio to receive letrozole (2.5 mg) or clomiphene citrate (100 mg) during 3-7 days of their menstrual cycle. Patients were matched on the basis of age, body mass index and polycystic ovary syndrome. Numbers size and growth of ovarian follices , hormonal factors and side effects of drugs were studied. Results: 48 patients with a mean age of 30.33±7.9 years old completed the trial. The mean time of follicle maturation in letrozole group (13.54±1.3 days) as compared with clomiphene citrate group (14.29±0.9 days) show significant difference with P <0.05. There was not statistically significant differences in numbers and size of mature follicles or endometrial thickness and drug side effects in two groups. Conclusion: Ovarian stimulation of letrozole was similar to clomiphene citrate, therefore, it may be suggested that this drug be used in treatment of women with infertility due to ovarian disorders