Volume 12, Issue 4 (2-2021)
2021, 12(4): 46-54 |
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Ethics code: IR.MEDSAB.REC.1398.039
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Zarei M, Nakhzari Khodakheir J. The Effect of Combined Aerobic- Resistance Exercise Training on Serum Concentrations of CTRP3 and Interleukin-6 in Men with Type 2 Diabetes. North Khorasan University of Medical Sciences 2021; 12 (4) :46-54
URL: http://journal.nkums.ac.ir/article-1-2217-en.html
URL: http://journal.nkums.ac.ir/article-1-2217-en.html
1- Assistant Professor, Department of Physical Education and Sport Sciences, Faculty of Literature and Humanities, University of Neyshabur, Neyshabur, Iran , zarei.m8716@yahoo.com
2- Assistant Professor, Department of Sport Sciences, School of Human Sciences, University of Zabol, Zabol, Iran
2- Assistant Professor, Department of Sport Sciences, School of Human Sciences, University of Zabol, Zabol, Iran
Abstract: (1958 Views)
Introduction: Studies have shown that CTRP3, as an insulin-independent anti-inflammatory adipokine, affects metabolism and regulates glucose metabolism. The aim of this study was to investigate the effect of combined aerobic- resistance training on serum concentrations of CTRP3 and interleukin-6 in men with type 2 diabetes.
Methods: In this quasi-experimental study, 24 male patients with type 2 diabetes were randomly divided into two groups of combined resistance aerobic exercise (n = 12) and control (n = 12). The subjects of the training group performed combined aerobic- resistance exercises 3 sessions per week for 12 weeks. Before and after 12 weeks of exercise program, blood samples were taken to measure the concentration of CTRP3 and interleukin-6 and anthropometric measurements of the subjects. Analysis of covariance was used to analyze the data.
Results: After 12 weeks in the exercise group, fasting glucose (P = 0.014), HbA1c (P = 0.001), body weight (P = 0.048), body mass index (P = 0.037), body fat percentage (P = 0.001), fat mass (P = 0.001) were significantly decreased compared to the control group, but there was a significant difference in insulin (P = 0.054), lean mass (P = 0.987) and WHR (P = 0.291) between the two groups. After 12 weeks, the concentration of CTRP3 (P = 0.040) in the training group increased and IL-6 (P = 0.028) concentration decreased significantly compared to the control group.
Conclusions: 12 weeks of combined aerobic- resistance training in men with type 2 diabetes in addition to glycemic control leads to a significant increase in CTRP3 and a significant decrease in interleukin-6.
Methods: In this quasi-experimental study, 24 male patients with type 2 diabetes were randomly divided into two groups of combined resistance aerobic exercise (n = 12) and control (n = 12). The subjects of the training group performed combined aerobic- resistance exercises 3 sessions per week for 12 weeks. Before and after 12 weeks of exercise program, blood samples were taken to measure the concentration of CTRP3 and interleukin-6 and anthropometric measurements of the subjects. Analysis of covariance was used to analyze the data.
Results: After 12 weeks in the exercise group, fasting glucose (P = 0.014), HbA1c (P = 0.001), body weight (P = 0.048), body mass index (P = 0.037), body fat percentage (P = 0.001), fat mass (P = 0.001) were significantly decreased compared to the control group, but there was a significant difference in insulin (P = 0.054), lean mass (P = 0.987) and WHR (P = 0.291) between the two groups. After 12 weeks, the concentration of CTRP3 (P = 0.040) in the training group increased and IL-6 (P = 0.028) concentration decreased significantly compared to the control group.
Conclusions: 12 weeks of combined aerobic- resistance training in men with type 2 diabetes in addition to glycemic control leads to a significant increase in CTRP3 and a significant decrease in interleukin-6.
Type of Study: Orginal Research |
Subject:
Basic Sciences
Received: 2020/09/26 | Accepted: 2020/12/16 | Published: 2021/02/28
Received: 2020/09/26 | Accepted: 2020/12/16 | Published: 2021/02/28
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