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JNKUMS 2021, 13(1): 64-76 Back to browse issues page
An Overview of Probiotics for Prevention and Treatment
Mohammadreza Safdari , Abdollah Razi , Molood Safarirad , Seyed Javad Pournaghi , Shima Shekari , Peiman Alesheikh , Maryam Rameshrad
Abstract:   (246 Views)
Introduction: Probiotics are living microorganisms that have beneficial effects on host health. They are mainly residents of the gastrointestinal tract. This study aimed to introduce the effects of probiotics in diseases such as obesity, diabetes, infertility, gastrointestinal diseases, and the effect on vaccination efficacy.
Methods: Herein, the newest relevant data that evaluated the effects of probiotics in the treatment of the aforementioned diseases were collected from Scopus and PubMed.
Results: The results showed that probiotics have a significant effect on controlling obesity and diabetes by regulating the balance of energy in the body. They modulate the level and type of autoantibodies, beta-cell autoimmunity and appetite-regulating hormones. Furthermore, these organisms reduce the absorption of dietary free fatty acids in the small intestine and increase the resistance of the intestinal barrier. Based on the gathered data, they are effective in improving bowel inflammatory disease, infertility, and depression by increasing the amount of pepsinogen and decreasing mucosal disorders and stress. They have a fantastic role in regulating the immune system, increasing sex hormones, and reducing inflammation. These microorganisms are also effective in improving the vaccination efficacy by regulating the production of antibodies and the cellular immune response.
Conclusions: Based on the results of this study, special species of probiotics could be considered a good candidate in adjuvant therapy of diseases that are related to human immunity dysfunction.
Keywords: Probiotics Obesity Diabetes Intestinal Inflammation Infertility
Full-Text [PDF 732 kb]   (132 Downloads)    
Type of Study: Orginal Research | Subject: Basic Sciences
Received: 2021/07/19 | Accepted: 2021/06/20 | Published: 2021/06/20
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Safdari M, Razi A, Safarirad M, Pournaghi S J, Shekari S, Alesheikh P et al . An Overview of Probiotics for Prevention and Treatment. JNKUMS. 2021; 13 (1) :64-76
URL: http://journal.nkums.ac.ir/article-1-2294-en.html


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Volume 13, Issue 1 (6-2021) Back to browse issues page
مجله دانشگاه علوم پزشکی خراسان شمالی Journal of North Khorasan University of Medical Sciences
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