Volume 13, Issue 3 (12-2021)
2021, 13(3): 51-56 |
Back to browse issues page
Ethics code: IR.MUMS.FM.REC.1396.737
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Hojatpanah N, Askarizadeh F, Amel Jamehdar S, Farsiani H, Ghazvini K. Evaluation Drug Susceptibility of Clinical Isolates of Mycobacterium Simiea Using REMA Plate Method in Mashhad. North Khorasan University of Medical Sciences 2021; 13 (3) :51-56
URL: http://journal.nkums.ac.ir/article-1-2434-en.html
URL: http://journal.nkums.ac.ir/article-1-2434-en.html
Noshin Hojatpanah1 
, Fatemeh Askarizadeh1 , Saeid Amel Jamehdar *2 
, Hadi Farsiani3 , Kiarash Ghazvini4
, Fatemeh Askarizadeh1 , Saeid Amel Jamehdar *2 , Hadi Farsiani3 , Kiarash Ghazvini4
1- Master of science Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2- Assistant Professor Department of Microbiology and Virology, Emam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran ,amelJS@mums.ac.ir
3- Assistant Professor Department of Microbiology and Virology, Emam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4- Associate professor Department of Microbiology and Virology, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2- Assistant Professor Department of Microbiology and Virology, Emam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran ,
3- Assistant Professor Department of Microbiology and Virology, Emam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4- Associate professor Department of Microbiology and Virology, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract: (1883 Views)
Introduction: Non-tuberculous species of Mycobacterium are a large group of Mycobacterium and are widely distributed throughout the world. Increased isolation of non-tuberculous mycobacteria from patients with mycobacteria infections in Iranian laboratories was associated with erroneous and unnecessary drug treatment, so that in some cases isolated strains considered as drug resistant strains. According to studies conducted in Iran, Mycobacterium simiae was one of the most abundant non-tuberculous mycobacteria. The treatment regimen used includes Moxifloxacin, Clarithromycin along with third drugs Trimethoprim-Sulfamethoxazole and Streptomycin antibiotics. Due to the limited studies performed on Mycobacterium simiae, in this study, the resistance of Mycobacterium simiae to common antibiotics used in the treatment regimen was evaluated by using the REMA Plate method.
Methods: In the present study, the drug susceptibility of 10 clinical isolates of Mycobacterium simiae to Clarithromycin, Moxifloxacin, Co-trimoxazole and Streptomycin antibiotics was evaluated using the REMA Plate method.
Results: Out of 10 samples, all samples were sensitive to streptomycin and clarithromycin antibiotics (100%) and resistance to Moxifloxacin and Co-trimoxazole were %10 and %60, respectively.
Conclusions: The results indicated that the most effective drugs for the treatment were Clarithromycin, Streptomycin and Moxifloxacin, which can be used as a proper regimen in the treatment of Mycobacterium simiae infection.
Methods: In the present study, the drug susceptibility of 10 clinical isolates of Mycobacterium simiae to Clarithromycin, Moxifloxacin, Co-trimoxazole and Streptomycin antibiotics was evaluated using the REMA Plate method.
Results: Out of 10 samples, all samples were sensitive to streptomycin and clarithromycin antibiotics (100%) and resistance to Moxifloxacin and Co-trimoxazole were %10 and %60, respectively.
Conclusions: The results indicated that the most effective drugs for the treatment were Clarithromycin, Streptomycin and Moxifloxacin, which can be used as a proper regimen in the treatment of Mycobacterium simiae infection.
Type of Study: Orginal Research |
Subject:
Basic Sciences
Received: 2021/01/9 | Accepted: 2021/05/11 | Published: 2021/12/1
Received: 2021/01/9 | Accepted: 2021/05/11 | Published: 2021/12/1
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
