Volume 13, Issue 4 (3-2022)
2022, 13(4): 59-65 |
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Ethics code: IR.IAU.M.REC.1399.033
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Shams B, Abedi B, Hosseini S A. The Effect of a Period of Resistance Training on BDNF Gene Depletion and Poor Memory of Rats Poisoned with Anabolic Steroid Stanazolol. North Khorasan University of Medical Sciences 2022; 13 (4) :59-65
URL: http://journal.nkums.ac.ir/article-1-2504-en.html
URL: http://journal.nkums.ac.ir/article-1-2504-en.html
1- PhD Student in Sports Physiology, Department of Physical Education, Islamic Azad University, Mahallat, Iran
2- Professor, Department of Physical Education, Mahallat Branch, Islamic Azad University, Mahallat, Iran , abedi@iaumahallat.ac.ir
3- Associate Professor of Sports Physiology, Department of Physical Education and Sports Science, Islamic Azad University, Marvdasht, Iran
2- Professor, Department of Physical Education, Mahallat Branch, Islamic Azad University, Mahallat, Iran , abedi@iaumahallat.ac.ir
3- Associate Professor of Sports Physiology, Department of Physical Education and Sports Science, Islamic Azad University, Marvdasht, Iran
Abstract: (1459 Views)
Introduction: Nowadays, the use of energy substances has become a complex problem in sports, in which the role of anabolic-androgenic asteroids is undeniable. The aim of this study was to evaluate the effect of a period of resistance training on BDNF gene expression and poor memory in rats poisoned with anabolic steroid stanazolol.
Methods: In this experimental study, 18 Sprague-Dovali rats with a weight range of 150 to 200 g and an average age of 8 weeks were randomly divided into three groups of 6 series including 1) sham (normal saline intake), 2) stanazole, 3) Stanazol was administered with resistance training. For eight weeks, the stanazol and resistance training + stanazole groups received 5 mg / kg of stanazole peritoneally daily, and the resistance training + stanazol group performed three sessions per week of resistance training. BDNF was measured in hippocampal tissue by ELISA and retention memory using shuttle box test. Kolmogorov-Smirnov test was used to evaluate the normality of the distribution of findings and one-way analysis of variance with Tukey post hoc test in SPSS software was used to analyze the results (P≥0.05).
Results: Stanazolol had a significant effect on reducing BDNF gene expression and nausea memory (P ≤ 0.001). However, resistance training increased BDNF (P ≤ 0.001) and nausea memory (P ≤ 0.006) in mice. Field poisoned with stanazolol.
Conclusions: According to the results of the present study, it seems that resistance training has synergistic effects on improving BDNF and laziness in rats poisoned with stanazol.
Methods: In this experimental study, 18 Sprague-Dovali rats with a weight range of 150 to 200 g and an average age of 8 weeks were randomly divided into three groups of 6 series including 1) sham (normal saline intake), 2) stanazole, 3) Stanazol was administered with resistance training. For eight weeks, the stanazol and resistance training + stanazole groups received 5 mg / kg of stanazole peritoneally daily, and the resistance training + stanazol group performed three sessions per week of resistance training. BDNF was measured in hippocampal tissue by ELISA and retention memory using shuttle box test. Kolmogorov-Smirnov test was used to evaluate the normality of the distribution of findings and one-way analysis of variance with Tukey post hoc test in SPSS software was used to analyze the results (P≥0.05).
Results: Stanazolol had a significant effect on reducing BDNF gene expression and nausea memory (P ≤ 0.001). However, resistance training increased BDNF (P ≤ 0.001) and nausea memory (P ≤ 0.006) in mice. Field poisoned with stanazolol.
Conclusions: According to the results of the present study, it seems that resistance training has synergistic effects on improving BDNF and laziness in rats poisoned with stanazol.
Type of Study: Orginal Research |
Subject:
Basic Sciences
Received: 2021/04/7 | Accepted: 2021/05/30 | Published: 2022/03/1
Received: 2021/04/7 | Accepted: 2021/05/30 | Published: 2022/03/1
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