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2022, 14(1): 1-8 |
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Ashofteh A, Cheragh-Birjandi S, TaheriChadorneshin H. The Effect of Resistance Training Along with Royal Jelly Supplementation on Expression of Nerve Growth Factor and Tyrosine Kinase A Receptor in the Hippocampal Tissue of Alzheimer's Rats. North Khorasan University of Medical Sciences 2022; 14 (1) :1-8
URL: http://journal.nkums.ac.ir/article-1-2560-en.html
URL: http://journal.nkums.ac.ir/article-1-2560-en.html
1- PhD in Exercise Physiology, Department of Sport Sciences, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran
2- Assistance Professor in Exercise Physiology, Department of Sport Sciences, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran ,s_birjandi2001@yahoo.com
3- Assistance Professor in Exercise Physiology, Department of Sport Sciences, University of Bojnord, Bojnord, Iran
2- Assistance Professor in Exercise Physiology, Department of Sport Sciences, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran ,
3- Assistance Professor in Exercise Physiology, Department of Sport Sciences, University of Bojnord, Bojnord, Iran
Abstract: (2084 Views)
Introduction: Current study aimed to investigate the effects of resistance training (RT) along with royal jelly (RJ) supplementation on hippocampal expression of nerve growth factor (proNGF) and p75 receptor in a rat’s model of Alzheimer's disease.
Method: 42 male Sprague-Dawley rats were treated with Trimethyltin chloride (8 mg/kg). Then, the rats were randomly divided into seven equal groups control, RT, RT + supplementation of RJ 100 mg/kg (RT+RJ100), RT+supplementation of RJ200 (RT+RJ200), supplementation of RJ100, supplementation of RJ200, and sham group. Supplement groups received 100 and 200 mg/kg/day of RJ for eight weeks. The incremental RT protocol was performed for eight weeks, three weekly sessions at intensity according to 30-100% of body weight.
Results: The RT protocol significantly increased proNGF expression compared to the control group. In addition, RJ100 and RJ200 resulted in a significant increase in the expression of proNGF and p75. Furthermore, the interaction effect of RT+RJ100 and RT+RJ200 induced a considerable increase in proNGF and p75 expression. Also, the impact of RJ on proNGF and p75 expression was dose-dependent, and the effect of the 200 mg/kg dose was significantly higher than the 100 mg/kg dose.
Conclusion: Both RT protocol and RJ supplementation synergistically increase neurotrophin expression in the hippocampus of Alzheimer's rats. The effects of RJ in combination use are dose-dependent, with higher doses having higher effects on neurotrophin and receptor expression. In the case of using a single dose of RJ, a lower dose is more desirable
Method: 42 male Sprague-Dawley rats were treated with Trimethyltin chloride (8 mg/kg). Then, the rats were randomly divided into seven equal groups control, RT, RT + supplementation of RJ 100 mg/kg (RT+RJ100), RT+supplementation of RJ200 (RT+RJ200), supplementation of RJ100, supplementation of RJ200, and sham group. Supplement groups received 100 and 200 mg/kg/day of RJ for eight weeks. The incremental RT protocol was performed for eight weeks, three weekly sessions at intensity according to 30-100% of body weight.
Results: The RT protocol significantly increased proNGF expression compared to the control group. In addition, RJ100 and RJ200 resulted in a significant increase in the expression of proNGF and p75. Furthermore, the interaction effect of RT+RJ100 and RT+RJ200 induced a considerable increase in proNGF and p75 expression. Also, the impact of RJ on proNGF and p75 expression was dose-dependent, and the effect of the 200 mg/kg dose was significantly higher than the 100 mg/kg dose.
Conclusion: Both RT protocol and RJ supplementation synergistically increase neurotrophin expression in the hippocampus of Alzheimer's rats. The effects of RJ in combination use are dose-dependent, with higher doses having higher effects on neurotrophin and receptor expression. In the case of using a single dose of RJ, a lower dose is more desirable
Type of Study: Orginal Research |
Subject:
Basic Sciences
Received: 2021/07/12 | Accepted: 2022/01/3 | Published: 2022/05/31
Received: 2021/07/12 | Accepted: 2022/01/3 | Published: 2022/05/31
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