Journal of North Khorasan

Abstract Background & Objectives: Currently glucantime is used as first choice drug in treating kala- azar. Because of some rising unresponsiveness to this drug, in this study we attempt to compare glucantime with amphotericin B in treatment of kala-azar as first line of therapy. Material & Methods: In these prospective study 19 patients aged 6.5 months to 10 years old with kalaazar were assessed. 12 out of 19 cases received amphotericn B and remainder treated with glucantime. Results: Fever and throm bocytopenia were improved more rapidly in amphotericin B taking group. (P 0.05 and P 0.017 respectively). Two cases were died who belonged to glucantime treated group (p 0.02) all patients who received amphotericin B were successfully cured. Conclusion: Am photericin B can cure kalazar fully with improving fever and thrombocytopenia quicker than glucantime