Journal of North Khorasan

Background & Objectives: sinusitis is a common upper respiratory tract infection and antibiotics almost always are selected empirically based on sensitivity of microorganisms to antibacterial agents. Finding alternative agents with herbal origin to broad spectrum antibiotics for treatment of sinusitis could be a valuable and safe therapeutic method. Viola Odorata contains some anti-microbial agents which can open a new horizon for controlling and treating microbial infections of upper respiratory tract. Materials & Methods: The herb which was collected from north Khorasan province was macerated and water and methanolic extracts were obtained. The antibacterial potency was evaluated by disc and well diffusion method. Results: for water extract, Inhibition zone of Staphylococcus epidermidis in well and disc diffusion method were (11 &12 millimeters) respectively. For methanol extract were (13 &15 mm) respectively. Also inhibition zone of Staphylococcus eureous was (11 &12 mm) with water extract and (11 & 13 mm) in methanol extract. Two extract didn’t have any effect on Entrobacter aeroginosa. Conclusion: as it can be seen, water extracts have the smallest inhibition zone, so it can be concluded that these extracts do not contain strong antimicrobial factors. On the other hand methanolic extracts with large inhibition zones should have effective and strong antimicrobial agents.