Volume 15, Issue 3 (Autumn 2023)
nkums 2023, 15(3): 37-42 |
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Nooryazdan A, Zinivand M, Ghorbanzadeh V, Beiranvand H, Khalili Alborz A, Nazari A. Effect of Hydroalcoholic Extract of Ginger on Cardiac Parameters in Male Rats with Renovascular Hypertension. nkums 2023; 15 (3) :37-42
URL: http://journal.nkums.ac.ir/article-1-2824-en.html
URL: http://journal.nkums.ac.ir/article-1-2824-en.html
Aram Nooryazdan1 
, Mahtab Zinivand1 , Vajihe Ghorbanzadeh2 , Hossein Beiranvand1 , Azadeh Khalili Alborz3 , Afshin Nazari *4
, Mahtab Zinivand1 , Vajihe Ghorbanzadeh2 , Hossein Beiranvand1 , Azadeh Khalili Alborz3 , Afshin Nazari *4
1- Master of Science, Department of Medical Physiology, Lorestan University of Medical Sciences, Khorramabad, Iran
2- professor, Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of medical science, Khorramabad, Iran
3- Assistant Professor, Department of Physiology, Pharmacology, and Medical Physics, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
4- professor, Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of medical science, Khorramabad, Iran ,nazary257@yahoo.com
2- professor, Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of medical science, Khorramabad, Iran
3- Assistant Professor, Department of Physiology, Pharmacology, and Medical Physics, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
4- professor, Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of medical science, Khorramabad, Iran ,
Abstract: (2338 Views)
Introduction: High blood pressure is one of the most important concerns of the healthcare system, especially in low- and middle-income countries. In the present study, we aimed to investigate the protective effect of the hydromethanolic extract of ginger on cardiac parameters in male rats with renovascular hypertension.
Method: A total of 54 rats were randomly divided into 6 groups as follows: control, hypertensive group, hypertensive group (hydromethanolic extract of ginger with a dose of 100 mg/kg), hypertensive group (hydromethanolic extract of ginger with a dose of 200 mg/kg), hypertensive group (hydromethanolic extract of ginger with a dose of 300 mg/kg), and surgical group receiving hydromethanolic extract of ginger with a dose of 200 mg/kg. Rats were gavaged for 42 days, once every day, using hydromethanol extract of ginger. Afterward, the heart rate was measured every 7 days. Ejection fraction (EF) and cardiac index were evaluated by SPSS-16 at a significance level of 0.05.
Results: The results of the study showed that the hydroethanolic extract of ginger caused a significant decrease in heart rate in the group without induced blood pressure receiving ginger extract (dose of 200 mg/kg) and in the induced blood pressure group gavaged ginger at a dose of 200 mg/kg. It was also found that there was a significant difference between the average EF in the studied groups; however, the cardiac index had no significant difference in the studied groups.
Conclusion: Hydroethanolic extract of ginger can reduce heart rate in hypertensive models and have a significant effect on cardiac output. Since ginger has no effect on cardiac index, studies with a longer duration of treatment are needed in this case, nevertheless, it can have a significant effect on ejection fraction
Method: A total of 54 rats were randomly divided into 6 groups as follows: control, hypertensive group, hypertensive group (hydromethanolic extract of ginger with a dose of 100 mg/kg), hypertensive group (hydromethanolic extract of ginger with a dose of 200 mg/kg), hypertensive group (hydromethanolic extract of ginger with a dose of 300 mg/kg), and surgical group receiving hydromethanolic extract of ginger with a dose of 200 mg/kg. Rats were gavaged for 42 days, once every day, using hydromethanol extract of ginger. Afterward, the heart rate was measured every 7 days. Ejection fraction (EF) and cardiac index were evaluated by SPSS-16 at a significance level of 0.05.
Results: The results of the study showed that the hydroethanolic extract of ginger caused a significant decrease in heart rate in the group without induced blood pressure receiving ginger extract (dose of 200 mg/kg) and in the induced blood pressure group gavaged ginger at a dose of 200 mg/kg. It was also found that there was a significant difference between the average EF in the studied groups; however, the cardiac index had no significant difference in the studied groups.
Conclusion: Hydroethanolic extract of ginger can reduce heart rate in hypertensive models and have a significant effect on cardiac output. Since ginger has no effect on cardiac index, studies with a longer duration of treatment are needed in this case, nevertheless, it can have a significant effect on ejection fraction
Type of Study: Orginal Research |
Subject:
Basic Sciences
Received: 2023/01/15 | Accepted: 2023/08/6 | Published: 2023/10/2
Received: 2023/01/15 | Accepted: 2023/08/6 | Published: 2023/10/2
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