Abstract Introduction: Lapse is a taking drug again after a period of time after stopping the drug. And due to the high incidence of lapse in drug addicts, this study surveys the affecting factors of lapse among the patients referring voluntarily to addiction-abandoning centers. Methods: This case-control study was conducted on 200 drug addicts that referred voluntarily to addiction-abandoning centers in Esfarayen-1391 and selected by cluster random sampling. Data were collected by researcher made questionnaire by interview and documents. Data were analyzed by SPSS18 statistical software presented with t-tests and chi-square. Results: Of 200 participants in the study, 77/5% were male, and mean of age was 45/9 years. Results showed that relationship between age (p=0/01), daily consumption (p=0/04), existing of chronic pain (p=0/02) and being with addicted friends (p=0/04) with lapse. But there was not relationship between smoking (p=0/32), type of treatment (p=0/18), marital status, education, employment and gender with lapse. Conclusion: According to the findings, education and intervention can change the affecting patterns of lapse and also strengthen coping skills in drug addicts for reduction of lapse.
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