Journal of North Khorasan

Abstract Background & objectives: High homocysteine level is considered as a risk factor for placental abruption. The purpose of this study is to determine the role of high homocysteine level in placental abruption. Material and Methods: This case- control study was conducted on 120 pregnant women (60 ones in case group and 60 in control group) who referred to Ayatollah Rouhani Hospital of Babol for delivery. Case group was women with clinical diagnosis of placenta abruption and control group was women without medical problems. Serum samples of fasting blood homocysteine were measured in a single lab. The obtained data were statistically analyzed after being collected. Results: Maternal age and number of deliveries in two groups showed no statistical difference. The mean serum homocysteine in mothers of case group was 10.76±1.55 micromoles and in mothers of control group was 8.48±1.65 micromoles. A significant statistical difference was observed between the serum homocysteine of mothers of two groups (p<0.001). There was a significant statistical relationship between the mean serum homocysteine in patients with history of abortion and gestational diabetes. Conclusion: Median level of serum homocysteine was higher in placenta abruption group and showed the role of hyper hemocysteinemia as a risk factor.