Volume 17, Issue 3 (Autumn 2025)
2025, 17(3): 11-30 |
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Haghbin A, Alizadeh Niknam A, Safarirad M, Feizi P, Vosughimotlagh A. Recent Advancements in the Usage of Polymeric Nanoparticles for Asthma Treatment. North Khorasan University of Medical Sciences 2025; 17 (3) :11-30
URL: http://journal.nkums.ac.ir/article-1-3261-en.html
URL: http://journal.nkums.ac.ir/article-1-3261-en.html
Ali Haghbin1 
, Amirahmad Alizadeh Niknam2 , Molood Safarirad3 , Peyman Feizi4 , Ahmad Vosughimotlagh *5
, Amirahmad Alizadeh Niknam2 , Molood Safarirad3 , Peyman Feizi4 , Ahmad Vosughimotlagh *5
1- Assistant Professor of Allergy and Clinical Immunology, Department of Pediatrics, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
2- School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
3- Assistant Professor of Pediatric Endocrinology and Metabolism, Department of Pediatrics, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
4- Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran
5- Assistant Professor of Allergy and Clinical Immunology, Department of Pediatrics, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran ,dr.ahmadvosughi@yahoo.com
2- School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
3- Assistant Professor of Pediatric Endocrinology and Metabolism, Department of Pediatrics, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
4- Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran
5- Assistant Professor of Allergy and Clinical Immunology, Department of Pediatrics, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran ,
Abstract: (267 Views)
Introduction: Asthma, a chronic inflammatory disorder of the airways, is marked by symptoms, including dyspnea, persistent cough, and wheezing. The pathophysiology of asthma involves sustained airway inflammation, often characterized by a significant eosinophilic infiltrate in lung tissue. This study aimed to explore the potential applications of nanotechnology in asthma therapeutics and help to develop effective asthma treatments.
Method: In this review study, the articles from 2010 to 2025 were collected by searching the databases ISI Web of Science, Science Direct, Scopus, PubMed, and Google Scholar, and using their content. Combined keywords, such as “Asthma”, “Polymeric Nanoparticles”, “PHPMA”, “PLGA”, and “PAMAM”, were used to search these databases. The articles were screened based on the relevance of the title and abstract, and irrelevant articles were excluded.
Results: Current treatments for asthma, such as inhaled glucocorticoids, beta-agonists, and leukotriene antagonists, face challenges, such as side effects and drug resistance. In recent years, nanotechnology has become an innovative approach to asthma management. Polymeric nanoparticles, including chitosan, PLGA, PAMAM, and PHPMA, have been acknowledged as effective drug carriers due to their biocompatibility, capacity to regulate drug release, and improve bioavailability.
Conclusion: These nanoparticles have great potential for enhancing asthma treatment by facilitating targeted drug delivery, decreasing the necessary dosage, and safeguarding the drug from degradation. This review study examined the application of polymeric nanoparticles in asthma treatment, compared them with lipidic nanoparticles, and discussed the role of nanotechnology in novel therapeutic and diagnostic approaches for asthma. It emphasized the necessity of expanding this technology to improve the effectiveness of treatment.
Method: In this review study, the articles from 2010 to 2025 were collected by searching the databases ISI Web of Science, Science Direct, Scopus, PubMed, and Google Scholar, and using their content. Combined keywords, such as “Asthma”, “Polymeric Nanoparticles”, “PHPMA”, “PLGA”, and “PAMAM”, were used to search these databases. The articles were screened based on the relevance of the title and abstract, and irrelevant articles were excluded.
Results: Current treatments for asthma, such as inhaled glucocorticoids, beta-agonists, and leukotriene antagonists, face challenges, such as side effects and drug resistance. In recent years, nanotechnology has become an innovative approach to asthma management. Polymeric nanoparticles, including chitosan, PLGA, PAMAM, and PHPMA, have been acknowledged as effective drug carriers due to their biocompatibility, capacity to regulate drug release, and improve bioavailability.
Conclusion: These nanoparticles have great potential for enhancing asthma treatment by facilitating targeted drug delivery, decreasing the necessary dosage, and safeguarding the drug from degradation. This review study examined the application of polymeric nanoparticles in asthma treatment, compared them with lipidic nanoparticles, and discussed the role of nanotechnology in novel therapeutic and diagnostic approaches for asthma. It emphasized the necessity of expanding this technology to improve the effectiveness of treatment.
Type of Study: Review Article |
Subject:
Basic Sciences
Received: 2025/07/2 | Accepted: 2025/08/25 | Published: 2025/09/29
Received: 2025/07/2 | Accepted: 2025/08/25 | Published: 2025/09/29
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