Volume 17, Issue 4 (Winter 2026)
2026, 17(4): 1-9 |
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Sangsefidi Z S, Toupchian O. The Role of Resveratrol in Vascular Intima-Media Thickness and Related Factors: A Narrative Review. North Khorasan University of Medical Sciences 2026; 17 (4) :1-9
URL: http://journal.nkums.ac.ir/article-1-3312-en.html
URL: http://journal.nkums.ac.ir/article-1-3312-en.html
1- Assistant Professor, Department of Nutrition Sciences, School of Public Health, North Khorasan University of Medical Sciences, Bojnord, Iran
2- Assistant Professor, Department of Nutrition Sciences, School of Public Health, North Khorasan University of Medical Sciences, Bojnord, Iran ,o.toupchian@gmail.com
2- Assistant Professor, Department of Nutrition Sciences, School of Public Health, North Khorasan University of Medical Sciences, Bojnord, Iran ,
Abstract: (25 Views)
Introduction: Cardiovascular diseases are the leading causes of death and disability worldwide. Recently, researchers have become interested in identifying nutritional supplements that can improve risk factors for these conditions. Intima-media thickness is recognized as a key risk factor for cardiovascular events. Resveratrol is a polyphenolic compound that has been extensively studied for its anticancer, anti-inflammatory, and anti-aging properties, as well as its potential role in the treatment of chronic diseases. Although studies directly investigating the effect of resveratrol on intima-media thickness are limited, related factors have been investigated in animal and human studies.
Method: This narrative review examines the evidence on the association between resveratrol and factors related to vascular intima-media thickness, and discusses the proposed mechanisms underlying this association.
Results: In general, research indicates that resveratrol reduces intima thickness, potentially by modulating cellular senescence and its antioxidant properties.
Conclusion: No human studies have directly examined the effect of this polyphenol on intima-media thickness, and further studies in this area are recommended.
Method: This narrative review examines the evidence on the association between resveratrol and factors related to vascular intima-media thickness, and discusses the proposed mechanisms underlying this association.
Results: In general, research indicates that resveratrol reduces intima thickness, potentially by modulating cellular senescence and its antioxidant properties.
Conclusion: No human studies have directly examined the effect of this polyphenol on intima-media thickness, and further studies in this area are recommended.
Type of Study: Review Article |
Subject:
Basic Sciences
Received: 2025/07/19 | Accepted: 2025/09/8 | Published: 2026/01/1
Received: 2025/07/19 | Accepted: 2025/09/8 | Published: 2026/01/1
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