Volume 18, Issue 3 (Autumn 2026)
nkums 2026, 18(3): 60-68 |
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Ethics code: IR.IAU.SRB.REC.1404.354
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Akbarzadeh Zarei H R, Gholami M, Ghareh S, Ghazalian F. The Effect of Aerobic Training and Cannabidiol Supplementation on Beta Cell Function and Pancreatic Tissue Structure in Rats Fed a High-Fat Diet. nkums 2026; 18 (3) :60-68
URL: http://journal.nkums.ac.ir/article-1-3428-en.html
URL: http://journal.nkums.ac.ir/article-1-3428-en.html
1- Department of Physical Education and Sport Sciences, SR.C., Islamic Azad University, Tehran, Iran
2- Department of Physical Education and Sport Sciences, SR.C., Islamic Azad University, Tehran, Iran ,mandanagholami@iau.ir
3- Farhikhtegan Medical Convergent Sciences Research Center, Farhikhtegan Hospital, Faculty of Medicine, TeMs. C., Islamic Azad University, Tehran, Iran
2- Department of Physical Education and Sport Sciences, SR.C., Islamic Azad University, Tehran, Iran ,
3- Farhikhtegan Medical Convergent Sciences Research Center, Farhikhtegan Hospital, Faculty of Medicine, TeMs. C., Islamic Azad University, Tehran, Iran
Abstract: (30 Views)
Introduction: This study aimed to investigate the effects of 8 weeks of aerobic training and cannabidiol (CBD) supplementation on beta-cell function and pancreatic tissue structure in rats fed a high-fat diet (HFD).
Methods: This experimental study used 32 male Wistar rats (8 weeks old). After 8 weeks of HFD, the rats were randomly divided into 4 groups: HFD, HFD+CBD, HFD+AE, and HFD+CBD+AE. The aerobic exercise program consisted of 5 sessions per week for 8 weeks on a treadmill for rodents. Rats in the supplement group received CBD at a dose of 10 mg/kg, either 2 hours after the training session on training days or at the same time on non-training days. Finally, pancreatic tissue was collected for histological examination.
Results: All therapeutic interventions, including CBD, AE, and CBD+AE, significantly reduced serum glucose, compared to the HFD group. However, insulin levels increased in the HFD+CBD group, compared to the HFD group (P=0.0281). The HOMA-IR index showed a significant decrease only in the HFD+AE group, compared to the HFD group (P=0.0342). Conversely, the HOMA-Beta index showed a significant increase only in the HFD+CBD (P=0.0002) and HFD+CBD+AE (P=0.0017) groups, compared to the HFD group.
Conclusion: These results suggest that although each of these interventions is beneficial on its own, the combination of aerobic exercise and cannabidiol supplementation may represent a more comprehensive and powerful therapeutic strategy to address pancreatic damage and metabolic disorders associated with obesity and diabetes.
Methods: This experimental study used 32 male Wistar rats (8 weeks old). After 8 weeks of HFD, the rats were randomly divided into 4 groups: HFD, HFD+CBD, HFD+AE, and HFD+CBD+AE. The aerobic exercise program consisted of 5 sessions per week for 8 weeks on a treadmill for rodents. Rats in the supplement group received CBD at a dose of 10 mg/kg, either 2 hours after the training session on training days or at the same time on non-training days. Finally, pancreatic tissue was collected for histological examination.
Results: All therapeutic interventions, including CBD, AE, and CBD+AE, significantly reduced serum glucose, compared to the HFD group. However, insulin levels increased in the HFD+CBD group, compared to the HFD group (P=0.0281). The HOMA-IR index showed a significant decrease only in the HFD+AE group, compared to the HFD group (P=0.0342). Conversely, the HOMA-Beta index showed a significant increase only in the HFD+CBD (P=0.0002) and HFD+CBD+AE (P=0.0017) groups, compared to the HFD group.
Conclusion: These results suggest that although each of these interventions is beneficial on its own, the combination of aerobic exercise and cannabidiol supplementation may represent a more comprehensive and powerful therapeutic strategy to address pancreatic damage and metabolic disorders associated with obesity and diabetes.
Type of Study: Orginal Research |
Subject:
Basic Sciences
Received: 2025/12/19 | Accepted: 2026/05/23 | Published: 2026/09/29
Received: 2025/12/19 | Accepted: 2026/05/23 | Published: 2026/09/29
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